The aging of hematopoietic stem cells

Sean J. Morrison, Antoni M. Wandycz, Koichi Akashi, Amiela Globerson, Irving L. Weissman

Research output: Contribution to journalArticle

557 Citations (Scopus)

Abstract

We have purified hematopoietic stem cells (HSCs) from the bone marrow of old mice and compared their properties to HSCs in young and middle-aged mice. Single, reconstituting HSCs (by limit dilution) from old and young mice exhibited indistinguishable progenitor activities in vivo. HSCs were five times as frequent in the bone marrow of old mice; however, HSCs from old mice were only one-quarter as efficient at homing to and engrafting the bone marrow of irradiated recipients. HSCs in young and middle-aged mice rarely were in the S/G2/M phases of the cell cycle, but HSCs in old mice were frequently in cycle. We speculate that the unexpected proliferation of HSCs in old mice might be related to the increased incidence of leukemia in old mice. HSCs change with age, but it is unknown whether these changes are determined intrinsically or caused by the aging of their environment.

Original languageEnglish
Pages (from-to)1011-1016
Number of pages6
JournalNature medicine
Volume2
Issue number9
DOIs
Publication statusPublished - Sep 1 1996
Externally publishedYes

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Hematopoietic Stem Cells
Stem cells
Aging of materials
Bone
Bone Marrow
G2 Phase
Cell Division
Dilution
Cell Cycle
Leukemia
Cells
Incidence

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Morrison, S. J., Wandycz, A. M., Akashi, K., Globerson, A., & Weissman, I. L. (1996). The aging of hematopoietic stem cells. Nature medicine, 2(9), 1011-1016. https://doi.org/10.1038/nm0996-1011

The aging of hematopoietic stem cells. / Morrison, Sean J.; Wandycz, Antoni M.; Akashi, Koichi; Globerson, Amiela; Weissman, Irving L.

In: Nature medicine, Vol. 2, No. 9, 01.09.1996, p. 1011-1016.

Research output: Contribution to journalArticle

Morrison, SJ, Wandycz, AM, Akashi, K, Globerson, A & Weissman, IL 1996, 'The aging of hematopoietic stem cells', Nature medicine, vol. 2, no. 9, pp. 1011-1016. https://doi.org/10.1038/nm0996-1011
Morrison SJ, Wandycz AM, Akashi K, Globerson A, Weissman IL. The aging of hematopoietic stem cells. Nature medicine. 1996 Sep 1;2(9):1011-1016. https://doi.org/10.1038/nm0996-1011
Morrison, Sean J. ; Wandycz, Antoni M. ; Akashi, Koichi ; Globerson, Amiela ; Weissman, Irving L. / The aging of hematopoietic stem cells. In: Nature medicine. 1996 ; Vol. 2, No. 9. pp. 1011-1016.
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