The agonist action of substituted phenylethanolamines on octopamine receptors in cockroach ventral nerve cords

Akinori Hirashima, Yoshii Yutaka, Eto Morifusa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

1. Effect of 72 ring or α-substituted phenylethanolamines (SPEAs) was examined on the adenylate cyclase prepared from ventral nerve cords of the American cockroach Periplaneta americana. 2. Para-Cl-SPEA was the most effective octopaminergic agonist, followed by p-Br-, p-F-, p-Me-, p-NO2- and p-CF3-SPEA. 3. Meta- and o-SPEAs were less active than p-SPEAs, in stimulating adenylate cyclase. 4. SPEA analogs interact with the same binding site as octopamine in the nerve cords of American cockroach, since the level of evoked cAMP production by a combination of optimally effective concentrations of octopamine and SPEA was not greater than the stimulation by octopamine alone. 5. Washing removed nearly all of the stimulatory activity of SPEA, suggesting that SPEA binds reversibly to the octopaminergic receptor.

Original languageEnglish
Pages (from-to)321-325
Number of pages5
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume103
Issue number2
DOIs
Publication statusPublished - Jan 1 1992

Fingerprint

Octopamine
Periplaneta
Cockroaches
Adenylyl Cyclases
Binding Sites
norsynephrine receptor

All Science Journal Classification (ASJC) codes

  • Immunology
  • Pharmacology

Cite this

The agonist action of substituted phenylethanolamines on octopamine receptors in cockroach ventral nerve cords. / Hirashima, Akinori; Yutaka, Yoshii; Morifusa, Eto.

In: Comparative Biochemistry and Physiology. Part C, Comparative, Vol. 103, No. 2, 01.01.1992, p. 321-325.

Research output: Contribution to journalArticle

@article{48688610cc7e4d83912d44b2d935d200,
title = "The agonist action of substituted phenylethanolamines on octopamine receptors in cockroach ventral nerve cords",
abstract = "1. Effect of 72 ring or α-substituted phenylethanolamines (SPEAs) was examined on the adenylate cyclase prepared from ventral nerve cords of the American cockroach Periplaneta americana. 2. Para-Cl-SPEA was the most effective octopaminergic agonist, followed by p-Br-, p-F-, p-Me-, p-NO2- and p-CF3-SPEA. 3. Meta- and o-SPEAs were less active than p-SPEAs, in stimulating adenylate cyclase. 4. SPEA analogs interact with the same binding site as octopamine in the nerve cords of American cockroach, since the level of evoked cAMP production by a combination of optimally effective concentrations of octopamine and SPEA was not greater than the stimulation by octopamine alone. 5. Washing removed nearly all of the stimulatory activity of SPEA, suggesting that SPEA binds reversibly to the octopaminergic receptor.",
author = "Akinori Hirashima and Yoshii Yutaka and Eto Morifusa",
year = "1992",
month = "1",
day = "1",
doi = "10.1016/0742-8413(92)90015-Y",
language = "English",
volume = "103",
pages = "321--325",
journal = "Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology",
issn = "1367-8280",
publisher = "Elsevier BV",
number = "2",

}

TY - JOUR

T1 - The agonist action of substituted phenylethanolamines on octopamine receptors in cockroach ventral nerve cords

AU - Hirashima, Akinori

AU - Yutaka, Yoshii

AU - Morifusa, Eto

PY - 1992/1/1

Y1 - 1992/1/1

N2 - 1. Effect of 72 ring or α-substituted phenylethanolamines (SPEAs) was examined on the adenylate cyclase prepared from ventral nerve cords of the American cockroach Periplaneta americana. 2. Para-Cl-SPEA was the most effective octopaminergic agonist, followed by p-Br-, p-F-, p-Me-, p-NO2- and p-CF3-SPEA. 3. Meta- and o-SPEAs were less active than p-SPEAs, in stimulating adenylate cyclase. 4. SPEA analogs interact with the same binding site as octopamine in the nerve cords of American cockroach, since the level of evoked cAMP production by a combination of optimally effective concentrations of octopamine and SPEA was not greater than the stimulation by octopamine alone. 5. Washing removed nearly all of the stimulatory activity of SPEA, suggesting that SPEA binds reversibly to the octopaminergic receptor.

AB - 1. Effect of 72 ring or α-substituted phenylethanolamines (SPEAs) was examined on the adenylate cyclase prepared from ventral nerve cords of the American cockroach Periplaneta americana. 2. Para-Cl-SPEA was the most effective octopaminergic agonist, followed by p-Br-, p-F-, p-Me-, p-NO2- and p-CF3-SPEA. 3. Meta- and o-SPEAs were less active than p-SPEAs, in stimulating adenylate cyclase. 4. SPEA analogs interact with the same binding site as octopamine in the nerve cords of American cockroach, since the level of evoked cAMP production by a combination of optimally effective concentrations of octopamine and SPEA was not greater than the stimulation by octopamine alone. 5. Washing removed nearly all of the stimulatory activity of SPEA, suggesting that SPEA binds reversibly to the octopaminergic receptor.

UR - http://www.scopus.com/inward/record.url?scp=0026480442&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026480442&partnerID=8YFLogxK

U2 - 10.1016/0742-8413(92)90015-Y

DO - 10.1016/0742-8413(92)90015-Y

M3 - Article

AN - SCOPUS:0026480442

VL - 103

SP - 321

EP - 325

JO - Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

JF - Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

SN - 1367-8280

IS - 2

ER -