The allantois and chorion, when isolated before circulation or chorio-allantoic fusion, have hematopoietic potential

Brandon M. Zeigler, Daisuke Sugiyama, Michael Chen, Yalin Guo, Karen M. Downs, Nancy A. Speck

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

The chorio-allantoic placenta forms through the fusion of the allantois (progenitor tissue of the umbilical cord), with the chorionic plate. The murine placenta contains high levels of hematopoietic stem cells, and is therefore a stem cell niche. However, it is not known whether the placenta is a site of hematopoietic cell emergence, or whether hematopoietic cells originate from other sites in the conceptus and then colonize the placenta. Here, we show that the allantois and chorion, isolated prior to the establishment of circulation, have the potential to give rise to myeloid and definitive erythroid cells following explant culture. We further show that the hematopoietic potential of the allantois and chorion does not require their union, indicating that it is an intrinsic property of these tissues. These results suggest that the placenta is not only a niche for, but also a source of, hematopoietic cells.

Original languageEnglish
Pages (from-to)4183-4192
Number of pages10
JournalDevelopment
Volume133
Issue number21
DOIs
Publication statusPublished - Nov 1 2006
Externally publishedYes

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Allantois
Chorion
Placenta
Stem Cell Niche
Erythroid Cells
Umbilical Cord
Hematopoietic Stem Cells

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

Cite this

The allantois and chorion, when isolated before circulation or chorio-allantoic fusion, have hematopoietic potential. / Zeigler, Brandon M.; Sugiyama, Daisuke; Chen, Michael; Guo, Yalin; Downs, Karen M.; Speck, Nancy A.

In: Development, Vol. 133, No. 21, 01.11.2006, p. 4183-4192.

Research output: Contribution to journalArticle

Zeigler, Brandon M. ; Sugiyama, Daisuke ; Chen, Michael ; Guo, Yalin ; Downs, Karen M. ; Speck, Nancy A. / The allantois and chorion, when isolated before circulation or chorio-allantoic fusion, have hematopoietic potential. In: Development. 2006 ; Vol. 133, No. 21. pp. 4183-4192.
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