The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum

Jie Liu, Kuniyoshi Shimizu, Fumiko Konishi, Shoichiro Kumamoto, Ryuichiro Kondo

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

The anti-androgenic activity of the ethanol extract of the fruiting body of Ganoderma lucidum has been previously reported. Ganoderol B with 5α-reductase inhibitory activity and the ability to bind to androgen receptor (AR) can inhibit androgen-induced LNCaP cell growth and suppress regrowth of the ventral prostate induced by testosterone in rats. The down-regulation of AR signaling by ganoderol B provides an important mechanism for its anti-androgenic activity. In view of the fact that PSA (prostatic specific antigen, a well-accepted prognostic indicator of prostate cancer) is down-regulated, an important implication of this study is that ganoderol B intervention strategy aimed at toning down the amplitude of androgen signaling could be helpful in controlling morbidity of prostate cancer. In conclusion, our result suggests that ganoderol B might be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.

Original languageEnglish
Pages (from-to)4966-4972
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume15
Issue number14
DOIs
Publication statusPublished - Jul 15 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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