Abstract
Trifluoperazine, a typical antipsychotic drug, not only antagonizes dopamine D2 receptors but also enhances serotonin 5-HT2 receptor-mediated behavior. Moreover, trifluoperazine suppresses human purinergic receptor P2X7 responses and calmodulin. However, the effect of trifluoperazine on marble-burying behavior, which has been considered an animal model of obsessive–compulsive disorder (OCD), has not been studied. Here, we examined the effect of trifluoperazine on marble-burying behavior in mice. Oral administration of paroxetine, a selective serotonin reuptake inhibitor, significantly reduced marble-burying behavior without affecting total locomotor activity. Similar results were obtained for trifluoperazine (3 mg/kg). The D2 receptor agonist, quinpirole (0.03 mg/kg, intraperitoneal [i.p.]), and 5-HT2A receptor antagonist, ketanserin (0.3 mg/kg, i.p.), significantly counteracted this reduction of marble-burying behavior by trifluoperazine. These results show that trifluoperazine reduces marble-burying behavior via D2 and 5-HT2A receptors, and may be a useful drug for the treatment of OCD.
| Original language | English |
|---|---|
| Pages (from-to) | 9-13 |
| Number of pages | 5 |
| Journal | Pharmacology Biochemistry and Behavior |
| Volume | 165 |
| DOIs | |
| Publication status | Published - Feb 1 2018 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience
Cite this
The antipsychotic trifluoperazine reduces marble-burying behavior in mice via D2 and 5-HT2A receptors : Implications for obsessive–compulsive disorder. / Egashira, Nobuaki; Kubota, Naoki; Goto, Yu; Watanabe, Takuya; Kubota, Kaori; Katsurabayashi, Shutaro; Iwasaki, Katsunori.
In: Pharmacology Biochemistry and Behavior, Vol. 165, 01.02.2018, p. 9-13.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The antipsychotic trifluoperazine reduces marble-burying behavior in mice via D2 and 5-HT2A receptors
T2 - Implications for obsessive–compulsive disorder
AU - Egashira, Nobuaki
AU - Kubota, Naoki
AU - Goto, Yu
AU - Watanabe, Takuya
AU - Kubota, Kaori
AU - Katsurabayashi, Shutaro
AU - Iwasaki, Katsunori
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Trifluoperazine, a typical antipsychotic drug, not only antagonizes dopamine D2 receptors but also enhances serotonin 5-HT2 receptor-mediated behavior. Moreover, trifluoperazine suppresses human purinergic receptor P2X7 responses and calmodulin. However, the effect of trifluoperazine on marble-burying behavior, which has been considered an animal model of obsessive–compulsive disorder (OCD), has not been studied. Here, we examined the effect of trifluoperazine on marble-burying behavior in mice. Oral administration of paroxetine, a selective serotonin reuptake inhibitor, significantly reduced marble-burying behavior without affecting total locomotor activity. Similar results were obtained for trifluoperazine (3 mg/kg). The D2 receptor agonist, quinpirole (0.03 mg/kg, intraperitoneal [i.p.]), and 5-HT2A receptor antagonist, ketanserin (0.3 mg/kg, i.p.), significantly counteracted this reduction of marble-burying behavior by trifluoperazine. These results show that trifluoperazine reduces marble-burying behavior via D2 and 5-HT2A receptors, and may be a useful drug for the treatment of OCD.
AB - Trifluoperazine, a typical antipsychotic drug, not only antagonizes dopamine D2 receptors but also enhances serotonin 5-HT2 receptor-mediated behavior. Moreover, trifluoperazine suppresses human purinergic receptor P2X7 responses and calmodulin. However, the effect of trifluoperazine on marble-burying behavior, which has been considered an animal model of obsessive–compulsive disorder (OCD), has not been studied. Here, we examined the effect of trifluoperazine on marble-burying behavior in mice. Oral administration of paroxetine, a selective serotonin reuptake inhibitor, significantly reduced marble-burying behavior without affecting total locomotor activity. Similar results were obtained for trifluoperazine (3 mg/kg). The D2 receptor agonist, quinpirole (0.03 mg/kg, intraperitoneal [i.p.]), and 5-HT2A receptor antagonist, ketanserin (0.3 mg/kg, i.p.), significantly counteracted this reduction of marble-burying behavior by trifluoperazine. These results show that trifluoperazine reduces marble-burying behavior via D2 and 5-HT2A receptors, and may be a useful drug for the treatment of OCD.
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U2 - 10.1016/j.pbb.2017.12.006
DO - 10.1016/j.pbb.2017.12.006
M3 - Article
VL - 165
SP - 9
EP - 13
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
ER -