The antipsychotic trifluoperazine reduces marble-burying behavior in mice via D2 and 5-HT2A receptors: Implications for obsessive–compulsive disorder

Nobuaki Egashira, Naoki Kubota, Yu Goto, Takuya Watanabe, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Trifluoperazine, a typical antipsychotic drug, not only antagonizes dopamine D2 receptors but also enhances serotonin 5-HT2 receptor-mediated behavior. Moreover, trifluoperazine suppresses human purinergic receptor P2X7 responses and calmodulin. However, the effect of trifluoperazine on marble-burying behavior, which has been considered an animal model of obsessive–compulsive disorder (OCD), has not been studied. Here, we examined the effect of trifluoperazine on marble-burying behavior in mice. Oral administration of paroxetine, a selective serotonin reuptake inhibitor, significantly reduced marble-burying behavior without affecting total locomotor activity. Similar results were obtained for trifluoperazine (3 mg/kg). The D2 receptor agonist, quinpirole (0.03 mg/kg, intraperitoneal [i.p.]), and 5-HT2A receptor antagonist, ketanserin (0.3 mg/kg, i.p.), significantly counteracted this reduction of marble-burying behavior by trifluoperazine. These results show that trifluoperazine reduces marble-burying behavior via D2 and 5-HT2A receptors, and may be a useful drug for the treatment of OCD.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume165
DOIs
Publication statusPublished - Feb 1 2018

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Receptor, Serotonin, 5-HT2A
Trifluoperazine
Calcium Carbonate
Antipsychotic Agents
Serotonin 5-HT2 Receptors
Purinergic P2X7 Receptors
Quinpirole
Serotonin 5-HT2 Receptor Antagonists
Ketanserin
Paroxetine
Dopamine D2 Receptors
Serotonin Uptake Inhibitors
Calmodulin
Locomotion
Oral Administration
Animals
Animal Models
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

The antipsychotic trifluoperazine reduces marble-burying behavior in mice via D2 and 5-HT2A receptors : Implications for obsessive–compulsive disorder. / Egashira, Nobuaki; Kubota, Naoki; Goto, Yu; Watanabe, Takuya; Kubota, Kaori; Katsurabayashi, Shutaro; Iwasaki, Katsunori.

In: Pharmacology Biochemistry and Behavior, Vol. 165, 01.02.2018, p. 9-13.

Research output: Contribution to journalArticle

Egashira, Nobuaki ; Kubota, Naoki ; Goto, Yu ; Watanabe, Takuya ; Kubota, Kaori ; Katsurabayashi, Shutaro ; Iwasaki, Katsunori. / The antipsychotic trifluoperazine reduces marble-burying behavior in mice via D2 and 5-HT2A receptors : Implications for obsessive–compulsive disorder. In: Pharmacology Biochemistry and Behavior. 2018 ; Vol. 165. pp. 9-13.
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