TY - JOUR
T1 - The antipsychotic trifluoperazine reduces marble-burying behavior in mice via D2 and 5-HT2A receptors
T2 - Implications for obsessive–compulsive disorder
AU - Egashira, Nobuaki
AU - Kubota, Naoki
AU - Goto, Yu
AU - Watanabe, Takuya
AU - Kubota, Kaori
AU - Katsurabayashi, Shutaro
AU - Iwasaki, Katsunori
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/2
Y1 - 2018/2
N2 - Trifluoperazine, a typical antipsychotic drug, not only antagonizes dopamine D2 receptors but also enhances serotonin 5-HT2 receptor-mediated behavior. Moreover, trifluoperazine suppresses human purinergic receptor P2X7 responses and calmodulin. However, the effect of trifluoperazine on marble-burying behavior, which has been considered an animal model of obsessive–compulsive disorder (OCD), has not been studied. Here, we examined the effect of trifluoperazine on marble-burying behavior in mice. Oral administration of paroxetine, a selective serotonin reuptake inhibitor, significantly reduced marble-burying behavior without affecting total locomotor activity. Similar results were obtained for trifluoperazine (3 mg/kg). The D2 receptor agonist, quinpirole (0.03 mg/kg, intraperitoneal [i.p.]), and 5-HT2A receptor antagonist, ketanserin (0.3 mg/kg, i.p.), significantly counteracted this reduction of marble-burying behavior by trifluoperazine. These results show that trifluoperazine reduces marble-burying behavior via D2 and 5-HT2A receptors, and may be a useful drug for the treatment of OCD.
AB - Trifluoperazine, a typical antipsychotic drug, not only antagonizes dopamine D2 receptors but also enhances serotonin 5-HT2 receptor-mediated behavior. Moreover, trifluoperazine suppresses human purinergic receptor P2X7 responses and calmodulin. However, the effect of trifluoperazine on marble-burying behavior, which has been considered an animal model of obsessive–compulsive disorder (OCD), has not been studied. Here, we examined the effect of trifluoperazine on marble-burying behavior in mice. Oral administration of paroxetine, a selective serotonin reuptake inhibitor, significantly reduced marble-burying behavior without affecting total locomotor activity. Similar results were obtained for trifluoperazine (3 mg/kg). The D2 receptor agonist, quinpirole (0.03 mg/kg, intraperitoneal [i.p.]), and 5-HT2A receptor antagonist, ketanserin (0.3 mg/kg, i.p.), significantly counteracted this reduction of marble-burying behavior by trifluoperazine. These results show that trifluoperazine reduces marble-burying behavior via D2 and 5-HT2A receptors, and may be a useful drug for the treatment of OCD.
UR - http://www.scopus.com/inward/record.url?scp=85038964970&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85038964970&partnerID=8YFLogxK
U2 - 10.1016/j.pbb.2017.12.006
DO - 10.1016/j.pbb.2017.12.006
M3 - Article
C2 - 29273456
AN - SCOPUS:85038964970
VL - 165
SP - 9
EP - 13
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
ER -