TY - JOUR
T1 - The association of antibodies against human T cell lymphotropic virus type I (HTLV-I) pX gene mutant products with HTLV-I-associated myelopathy/tropical spastic paraparesis
AU - Suzuki, Jun
AU - Kira, Jun Ichi
AU - Baba, Eishi
AU - Nakamura, Minoru
AU - Koyanagi, Yoshio
AU - Nakamura, Tatsufumi
AU - Kawano, Yuji
AU - Yamasaki, Kenji
AU - Shirabe, Susumu
AU - Hatano, Naoya
AU - Hayashi, Kenshi
AU - Yamamoto, Naoki
AU - Kobayashi, Takuro
PY - 1996
Y1 - 1996
N2 - Antibodies specific for the products of the human T cell lymphotropic virus type 1 (HTLV-I) pX frame-shift mutants were studied by ELISA. The serum IgG antibodies to the synthetic peptide corresponding to one nucleotide insertion at position 7784 were significantly more common in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients than in HTLV-I carriers who had neither HAM/TSP nor adult T cell leukemia (39% vs. 5%). The seropositivities to the other synthetic peptides, which corresponded to the one nucleotide deletion at position 7475 and the internal deletion of nt 7754-7819 and nt 7853-7936, were rare. A genetic study confirmed the presence of the responsible mutation of the pX gene in peripheral blood mononuclear cells and central nervous system tissue from HTLV-I-infected subjects with and without HAM/TSP. These results suggest that HTLV-I pX frame-shift mutants are expressed in vivo in HTLV-I carriers; they also induce antibodies, especially in those with HAM/TSP.
AB - Antibodies specific for the products of the human T cell lymphotropic virus type 1 (HTLV-I) pX frame-shift mutants were studied by ELISA. The serum IgG antibodies to the synthetic peptide corresponding to one nucleotide insertion at position 7784 were significantly more common in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients than in HTLV-I carriers who had neither HAM/TSP nor adult T cell leukemia (39% vs. 5%). The seropositivities to the other synthetic peptides, which corresponded to the one nucleotide deletion at position 7475 and the internal deletion of nt 7754-7819 and nt 7853-7936, were rare. A genetic study confirmed the presence of the responsible mutation of the pX gene in peripheral blood mononuclear cells and central nervous system tissue from HTLV-I-infected subjects with and without HAM/TSP. These results suggest that HTLV-I pX frame-shift mutants are expressed in vivo in HTLV-I carriers; they also induce antibodies, especially in those with HAM/TSP.
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U2 - 10.1093/infdis/173.5.1115
DO - 10.1093/infdis/173.5.1115
M3 - Article
C2 - 8627062
AN - SCOPUS:19144372179
SN - 0022-1899
VL - 173
SP - 1115
EP - 1122
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -