Nita et al. reveal that the CHD8-p53 axis plays a key role in regulation of the stemness and differentiation of hematopoietic stem cells (HSCs) in vitro and in vivo. CHD8 deficiency in HSCs results in cell cycle arrest, apoptosis, and a differentiation block, which are partially rescued by additional deletion of p53.
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)