The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells

Akihiro Nita, Yoshiharu Muto, Yuta Katayama, Akinobu Matsumoto, Masaaki Nishiyama, Keiichi I. Nakayama

Research output: Contribution to journalArticlepeer-review

Abstract

Nita et al. reveal that the CHD8-p53 axis plays a key role in regulation of the stemness and differentiation of hematopoietic stem cells (HSCs) in vitro and in vivo. CHD8 deficiency in HSCs results in cell cycle arrest, apoptosis, and a differentiation block, which are partially rescued by additional deletion of p53.

Original languageEnglish
Article number108688
JournalCell Reports
Volume34
Issue number5
DOIs
Publication statusPublished - Feb 2 2021

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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