@article{2c33830e7d234c2c88d264306d67c715,
title = "The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells",
abstract = "Nita et al. reveal that the CHD8-p53 axis plays a key role in regulation of the stemness and differentiation of hematopoietic stem cells (HSCs) in vitro and in vivo. CHD8 deficiency in HSCs results in cell cycle arrest, apoptosis, and a differentiation block, which are partially rescued by additional deletion of p53.",
author = "Akihiro Nita and Yoshiharu Muto and Yuta Katayama and Akinobu Matsumoto and Masaaki Nishiyama and Nakayama, {Keiichi I.}",
note = "Funding Information: We thank T. Akinaga, K. Tsunematsu, L. Cui, and other laboratory members for technical assistance, as well as A. Ohta for help with preparation of the manuscript. This study was supported in part by KAKENHI grants (18H05215 and 19H05220) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, Japan. Conceptualization, A.N. M.N. and K.I.N.; Methodology, A.N.; Formal Analysis, A.N.; Investigation, A.N. and Y.M.; Resources, Y.K.; Writing – Original Draft, A.N. A.M. and K.I.N.; Writing – Review & Editing, A.N. Y.K. and K.I.N.; Visualization, A.N.; Project Administration, K.I.N.; Funding Acquisition, K.I.N. The authors declare no competing interests. Funding Information: We thank T. Akinaga, K. Tsunematsu, L. Cui, and other laboratory members for technical assistance, as well as A. Ohta for help with preparation of the manuscript. This study was supported in part by KAKENHI grants (18H05215 and 19H05220) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, Japan . Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
month = feb,
day = "2",
doi = "10.1016/j.celrep.2021.108688",
language = "English",
volume = "34",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "5",
}