The beneficial effects of Kampo medicine Dai-Ken-Chu-To after hepatic resection

A prospective randomized control study

Masaki Nishi, Mitsuo Shimada, Hideaki Uchiyama, Toru Ikegami, Yusuke Arakawa, Jun Hanaoka, Hirofumi Kanemura, Yuji Morine, Satoru Imura, Hidenori Miyake, Toru Utsunomiya

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background/Aims: After hepatic resection, delayed flatus and impaired bowel movement often cause problematic postoperative ileus. Kampo medicine, Dai-kenchu-to (DKT), is reported to have a various beneficial effects on bowel systems. The aim of this study was to prospectively evaluate effects of DKT after hepatic resection. Methodology: Thirty-two patients who underwent hepatic resection between July 2007 and August 2008 in Tokushima University Hospital were prospectively divided into DKT group (n=16) and control group (n=16). In DKT group, 2.5g of DKT was administered orally three times a day from postoperative day (POD) 1. Blood was examined on POD 1, 3, 5 and 7. Postoperative first flatus, bowel movement and full recovery of oral intake, hospital stays and complications were checked. Results: In DKT group, levels of c-reactive protein and beta-(1-3)-D-glucan on POD 3 were significantly decreased (p<0.05). Moreover, postoperative periods for the first flatus, bowel movement and the full recovery of oral intake were significantly shortened in DKT group (p<0.05). Conclusions: DKT suppressed inflammatory reaction, stimulated bowel movement and improved oral intake after hepatic resection, which may decrease serious morbidity after hepatic resection.

Original languageEnglish
Pages (from-to)2290-2294
Number of pages5
JournalHepato-gastroenterology
Volume59
Issue number119
DOIs
Publication statusPublished - Oct 1 2012
Externally publishedYes

Fingerprint

Kampo Medicine
Liver
Flatulence
dai-kenchu-to
Ileus
Postoperative Period
Length of Stay
Morbidity
Control Groups

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

The beneficial effects of Kampo medicine Dai-Ken-Chu-To after hepatic resection : A prospective randomized control study. / Nishi, Masaki; Shimada, Mitsuo; Uchiyama, Hideaki; Ikegami, Toru; Arakawa, Yusuke; Hanaoka, Jun; Kanemura, Hirofumi; Morine, Yuji; Imura, Satoru; Miyake, Hidenori; Utsunomiya, Toru.

In: Hepato-gastroenterology, Vol. 59, No. 119, 01.10.2012, p. 2290-2294.

Research output: Contribution to journalArticle

Nishi, M, Shimada, M, Uchiyama, H, Ikegami, T, Arakawa, Y, Hanaoka, J, Kanemura, H, Morine, Y, Imura, S, Miyake, H & Utsunomiya, T 2012, 'The beneficial effects of Kampo medicine Dai-Ken-Chu-To after hepatic resection: A prospective randomized control study', Hepato-gastroenterology, vol. 59, no. 119, pp. 2290-2294. https://doi.org/10.5754/hge10115
Nishi, Masaki ; Shimada, Mitsuo ; Uchiyama, Hideaki ; Ikegami, Toru ; Arakawa, Yusuke ; Hanaoka, Jun ; Kanemura, Hirofumi ; Morine, Yuji ; Imura, Satoru ; Miyake, Hidenori ; Utsunomiya, Toru. / The beneficial effects of Kampo medicine Dai-Ken-Chu-To after hepatic resection : A prospective randomized control study. In: Hepato-gastroenterology. 2012 ; Vol. 59, No. 119. pp. 2290-2294.
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