The biological response to orthopaedic implants for joint replacement: Part I: Metals

Emmanuel Gibon, Derek F. Amanatullah, Florence Loi, Jukka Pajarinen, Akira Nabeshima, Zhenyu Yao, Moussa Hamadouche, Stuart B. Goodman

Research output: Contribution to journalReview articlepeer-review

44 Citations (Scopus)

Abstract

Joint replacement is a commonly performed, highly successful orthopaedic procedure, for which surgeons have a large choice of different materials and implant designs. The materials used for joint replacement must be both biologically acceptable to minimize adverse local tissue reactions, and robust enough to support weight bearing during common activities of daily living. Modern joint replacements are made from metals and their alloys, polymers, ceramics, and composites. This review focuses on the biological response to the different biomaterials used for joint replacement. In general, modern materials for joint replacement are well tolerated by the body as long as they are in bulk (rather than in particulate or ionic) form, are mechanically stable and noninfected. If the latter conditions are not met, the prosthesis will be associated with an acute/chronic inflammatory reaction, peri-prosthetic osteolysis, loosening and failure. This article (Part 1 of 2) is dedicated to the use of metallic devices in orthopaedic surgery including the associated biological response to metallic byproducts is a review of the basic science literature regarding this topic.

Original languageEnglish
Pages (from-to)2162-2173
Number of pages12
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume105
Issue number7
DOIs
Publication statusPublished - Oct 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

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