The biphasic changes in splenic natural killer cell activity following ventromedial hypothalamic lesions in rats

Toshihiko Katafuchi, Eiichiro Okada, Sachiko Take, Tetsuro Hori

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Abstract

The cytotoxic activity of natural killer (NK) cells in the spleen was measured by a standard 4-h chromium release assay following electrical lesioning of the ventromedial hypothalamic nucleus (VMH) in rats. The splenic NK cell activity of VMH lesioned rats was found to be significantly suppressed at effector: target cell ratios of 100:1 and 50:1 compared with that of sham lesioned rats on day 4 after the lesion. On the other hand, on day 49, the VMH lesioned animals that had become hyperphagic and obese showed an enhancement of splenic NK cell activity compared with sham lesioned animals. The mechanisms of the biphasic change in NK cell activity following the VMH lesions are discussed.

Original languageEnglish
Pages (from-to)164-168
Number of pages5
JournalBrain Research
Volume652
Issue number1
DOIs
Publication statusPublished - Jul 25 1994

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Ventromedial Hypothalamic Nucleus
Natural Killer Cells
Chromium
Spleen

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

The biphasic changes in splenic natural killer cell activity following ventromedial hypothalamic lesions in rats. / Katafuchi, Toshihiko; Okada, Eiichiro; Take, Sachiko; Hori, Tetsuro.

In: Brain Research, Vol. 652, No. 1, 25.07.1994, p. 164-168.

Research output: Contribution to journalArticle

Katafuchi, Toshihiko ; Okada, Eiichiro ; Take, Sachiko ; Hori, Tetsuro. / The biphasic changes in splenic natural killer cell activity following ventromedial hypothalamic lesions in rats. In: Brain Research. 1994 ; Vol. 652, No. 1. pp. 164-168.
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