The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats

Hiroshi Kajiwara, Takayoshi Yamaza, Masao Yoshinari, Tetsuya Goto, Shinji Iyama, Atsuta Ikiru, Mizuho A. Kido, Teruo Tanaka

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Many materials with differing surfaces have been developed for clinical implant therapy in dentistry and orthopedics. We analyzed the quantity of new bone formed in vivo around calcium-immobilized titanium implants with surfaces modified using pamidronate (PAM), a nitrogen-containing bisphosphonate (N-BP), implants of pure titanium, and titanium implants immobilized with calcium ions. New bone formation was visualized using fluorescent labeling (calcein blue and alizarin complexone) with intravenous injection at 1 and 3 weeks after implantation. After 4 weeks, undecalcified sections were prepared, and new bone formation around the implants was examined by morphometry using confocal laser scanning microscopy images. After 1 week, more new bone formed around the PAM-immobilized implant than around the calcium-immobilized and pure titanium implants. This was also seen with the new bone formation after 3 weeks. After 4 weeks, significantly more new bones were formed around the BP-immobilized implant than around the calcium ion-implanted and pure titanium implants. The new N-BP-modified titanium surface stimulates new bone formation around the implant, which might contribute to the success of implant therapy.

Original languageEnglish
Pages (from-to)581-587
Number of pages7
JournalBiomaterials
Volume26
Issue number6
DOIs
Publication statusPublished - Feb 1 2005

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pamidronate
Diphosphonates
Titanium
Osteogenesis
Rats
Bone
Calcium
Bone and Bones
Nitrogen
Ions
Alizarin
Dentistry
Confocal Microscopy
Intravenous Injections
Orthopedics
Labeling

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats. / Kajiwara, Hiroshi; Yamaza, Takayoshi; Yoshinari, Masao; Goto, Tetsuya; Iyama, Shinji; Ikiru, Atsuta; Kido, Mizuho A.; Tanaka, Teruo.

In: Biomaterials, Vol. 26, No. 6, 01.02.2005, p. 581-587.

Research output: Contribution to journalArticle

Kajiwara, Hiroshi ; Yamaza, Takayoshi ; Yoshinari, Masao ; Goto, Tetsuya ; Iyama, Shinji ; Ikiru, Atsuta ; Kido, Mizuho A. ; Tanaka, Teruo. / The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats. In: Biomaterials. 2005 ; Vol. 26, No. 6. pp. 581-587.
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