The C-terminal portion of an archaeal toxin, aRelE, plays a crucial role in protein synthesis inhibition

Chie Kikutake, Masaaki Shinohara, Hisanori Takagi, Takashi Nakashima, Makoto Kimura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mutations of amino acids in the C-terminal region of an archaeal toxin, aRelE, from Pyrococcus horikoshii were characterized with respect to protein synthesis inhibitory activity and 70S ribosome-binding activity. The results suggest that basic residues at the C-terminal region in aRelE play a crucial role both in 70S ribosome binding and in protein synthesis inhibition activities.

Original languageEnglish
Pages (from-to)2766-2768
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume73
Issue number12
DOIs
Publication statusPublished - Dec 1 2009

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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