The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity

Gillian J. Wilson, Mohlopheni J. Marakalala, Jennifer C. Hoving, Arjan Van Laarhoven, Rebecca A. Drummond, Bernhard Kerscher, Roanne Keeton, Esther Van De Vosse, Tom H.M. Ottenhoff, Theo S. Plantinga, Bachti Alisjahbana, Dhirendra Govender, Gurdyal S. Besra, Mihai G. Netea, Delyth M. Reid, Janet A. Willment, Muazzam Jacobs, Sho Yamasaki, Reinout Van Crevel, Gordon D. Brown

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Abstract

    The interaction of microbes with pattern recognition receptors (PRRs) is essential for protective immunity. While many PRRs that recognize mycobacteria have been identified, none is essentially required for host defense in vivo. Here, we have identified the C-type lectin receptor CLECSF8 (CLEC4D, MCL) as a key molecule in anti-mycobacterial host defense. Clecsf8-/- mice exhibit higher bacterial burdens and increased mortality upon M. tuberculosis infection. Additionally, Clecsf8 deficiency is associated with exacerbated pulmonary inflammation, characterized by enhanced neutrophil recruitment. Clecsf8-/- mice show reduced mycobacterial uptake by pulmonary leukocytes, but infection with opsonized bacteria can restore this phagocytic defect as well as decrease bacterial burdens. Notably, a CLECSF8 polymorphism identified in humans is associated with an increased susceptibility to pulmonary tuberculosis. We conclude that CLECSF8 plays a non-redundant role in anti-mycobacterial immunity in mouse and in man.

    Original languageEnglish
    Pages (from-to)252-259
    Number of pages8
    JournalCell Host and Microbe
    Volume17
    Issue number2
    DOIs
    Publication statusPublished - Feb 11 2015

    Fingerprint

    C-Type Lectins
    Pattern Recognition Receptors
    Immunity
    Neutrophil Infiltration
    Mycobacterium
    Infection
    Pulmonary Tuberculosis
    Pneumonia
    Tuberculosis
    Leukocytes
    Bacteria
    Lung
    Mortality

    All Science Journal Classification (ASJC) codes

    • Parasitology
    • Microbiology
    • Virology

    Cite this

    Wilson, G. J., Marakalala, M. J., Hoving, J. C., Van Laarhoven, A., Drummond, R. A., Kerscher, B., ... Brown, G. D. (2015). The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity. Cell Host and Microbe, 17(2), 252-259. https://doi.org/10.1016/j.chom.2015.01.004

    The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity. / Wilson, Gillian J.; Marakalala, Mohlopheni J.; Hoving, Jennifer C.; Van Laarhoven, Arjan; Drummond, Rebecca A.; Kerscher, Bernhard; Keeton, Roanne; Van De Vosse, Esther; Ottenhoff, Tom H.M.; Plantinga, Theo S.; Alisjahbana, Bachti; Govender, Dhirendra; Besra, Gurdyal S.; Netea, Mihai G.; Reid, Delyth M.; Willment, Janet A.; Jacobs, Muazzam; Yamasaki, Sho; Van Crevel, Reinout; Brown, Gordon D.

    In: Cell Host and Microbe, Vol. 17, No. 2, 11.02.2015, p. 252-259.

    Research output: Contribution to journalArticle

    Wilson, GJ, Marakalala, MJ, Hoving, JC, Van Laarhoven, A, Drummond, RA, Kerscher, B, Keeton, R, Van De Vosse, E, Ottenhoff, THM, Plantinga, TS, Alisjahbana, B, Govender, D, Besra, GS, Netea, MG, Reid, DM, Willment, JA, Jacobs, M, Yamasaki, S, Van Crevel, R & Brown, GD 2015, 'The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity', Cell Host and Microbe, vol. 17, no. 2, pp. 252-259. https://doi.org/10.1016/j.chom.2015.01.004
    Wilson GJ, Marakalala MJ, Hoving JC, Van Laarhoven A, Drummond RA, Kerscher B et al. The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity. Cell Host and Microbe. 2015 Feb 11;17(2):252-259. https://doi.org/10.1016/j.chom.2015.01.004
    Wilson, Gillian J. ; Marakalala, Mohlopheni J. ; Hoving, Jennifer C. ; Van Laarhoven, Arjan ; Drummond, Rebecca A. ; Kerscher, Bernhard ; Keeton, Roanne ; Van De Vosse, Esther ; Ottenhoff, Tom H.M. ; Plantinga, Theo S. ; Alisjahbana, Bachti ; Govender, Dhirendra ; Besra, Gurdyal S. ; Netea, Mihai G. ; Reid, Delyth M. ; Willment, Janet A. ; Jacobs, Muazzam ; Yamasaki, Sho ; Van Crevel, Reinout ; Brown, Gordon D. / The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity. In: Cell Host and Microbe. 2015 ; Vol. 17, No. 2. pp. 252-259.
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