The CCL20 and CCR6 axis in psoriasis

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Abstract

Psoriasis is a TNF-α/IL-23/IL-17A–mediated inflammatory skin disease that causes a significant socioeconomic burden in afflicted patients. IL-17A–producing immune cells, including Th17 cells, are crucial effector cells in the development of psoriasis. IL-17A stimulates epidermal keratinocytes to produce CCL20, which eventually recruits CCR6 + Th17 cells into the lesional skin. Thus, the CCL20/CCR6 axis works as a driving force that prepares an IL-17A–rich cutaneous milieu. In this review, we summarize the current research topics on the CCL20/CCR6 axis and the therapeutic intervention of this axis for psoriasis.

Original languageEnglish
Article numbere12846
JournalScandinavian Journal of Immunology
Volume91
Issue number3
DOIs
Publication statusPublished - Mar 1 2020

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All Science Journal Classification (ASJC) codes

  • Immunology

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