The cellular receptor tot measles virus - Elusive no more

Research output: Contribution to journalReview article

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Abstract

The identity of the measles virus receptor has been controversial. Several years ago CD46 was identified as a cellular receptor for the Edmonston strain of measles virus, but most clinical isolates of measles virus, which are most efficiently isolated in the marmoset B cell line B95a, cannot grow in many CD46+ cell lines. Although some researchers attributed it to post-entry block in viral replication, others believed that there is a receptor other than CD46 for wild-type measles viruses. A new study showed that human signalling lymphocytic activation molecule (SLAM; also known as CDw150) is a cellular receptor for measles virus, including the Edmonston strain. SLAM is expressed on lymphocytes and dendritic cells, and plays an important role in lymphocyte activation. The identification of SLAM as a measles virus receptor nicely explains the pathogenesis of measles virus infection.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalReviews in Medical Virology
Volume11
Issue number3
DOIs
Publication statusPublished - Jun 18 2001

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All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

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