The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice

Takafumi Fuchiwaki, Xun Sun, Kenjiro Fujimura, Hisakata Yamada, Kensuke Shibata, Hiromi Muta, Eckhard R. Podack, Hideyuki Kawauchi, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    CD30 ligand (CD30L) plays an important role in the amplification and/or activation of effector CD4 + T cells, irrespective of Th cell subset. To examine the role of CD30L in allergic rhinitis, we evaluated an OVA model of allergic rhinitis in CD30L knock out (KO) mice on a BALB/c background sensitized with OVA. Symptoms of allergic rhinitis such as eosinophil infiltration into the nasal mucosa were drastically diminished in OVA-sensitized CD30L KO mice following intranasal challenge with OVA. The levels of OVA-specific IgE in the sera and the Th2 response in nasopharynx-associated lymphoid tissues and cervical LNs of CD30L KO mice were significantly lower than those of WT mice following intranasal challenge with OVA. Intranasal administration of CD30-Ig during the effector phase with OVA significantly prevented the development of allergic rhinitis in WT mice. These results suggest that CD30L plays an important role in allergic rhinitis and that the inhibition of CD30L/CD30 signaling might be useful as a novel biological therapy for allergic rhinitis.

    Original languageEnglish
    Pages (from-to)2947-2954
    Number of pages8
    JournalEuropean Journal of Immunology
    Volume41
    Issue number10
    DOIs
    Publication statusPublished - Oct 1 2011

    Fingerprint

    CD30 Ligand
    Knockout Mice
    Intranasal Administration
    Biological Therapy
    Nasopharynx
    Nasal Mucosa
    Lymphoid Tissue
    Allergic Rhinitis
    Eosinophils
    Immunoglobulin E
    T-Lymphocytes

    All Science Journal Classification (ASJC) codes

    • Immunology
    • Immunology and Allergy

    Cite this

    Fuchiwaki, T., Sun, X., Fujimura, K., Yamada, H., Shibata, K., Muta, H., ... Yoshikai, Y. (2011). The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice. European Journal of Immunology, 41(10), 2947-2954. https://doi.org/10.1002/eji.201141423

    The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice. / Fuchiwaki, Takafumi; Sun, Xun; Fujimura, Kenjiro; Yamada, Hisakata; Shibata, Kensuke; Muta, Hiromi; Podack, Eckhard R.; Kawauchi, Hideyuki; Yoshikai, Yasunobu.

    In: European Journal of Immunology, Vol. 41, No. 10, 01.10.2011, p. 2947-2954.

    Research output: Contribution to journalArticle

    Fuchiwaki, T, Sun, X, Fujimura, K, Yamada, H, Shibata, K, Muta, H, Podack, ER, Kawauchi, H & Yoshikai, Y 2011, 'The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice', European Journal of Immunology, vol. 41, no. 10, pp. 2947-2954. https://doi.org/10.1002/eji.201141423
    Fuchiwaki, Takafumi ; Sun, Xun ; Fujimura, Kenjiro ; Yamada, Hisakata ; Shibata, Kensuke ; Muta, Hiromi ; Podack, Eckhard R. ; Kawauchi, Hideyuki ; Yoshikai, Yasunobu. / The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice. In: European Journal of Immunology. 2011 ; Vol. 41, No. 10. pp. 2947-2954.
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