The coalescent with selection on copy number variants

Kosuke M. Teshima, Hideki Innan

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We develop a coalescent-based simulation tool to generate patterns of single nucleotide polymorphisms (SNPs) in a wide region encompassing both the original and duplicated genes. Selection on the new duplicated copy and interlocus gene conversion between the two copies are incorporated. This simulation enables us to explore how selection on duplicated copies affects the pattern of SNPs. The fixation of an advantageous duplicated copy causes a strong reduction in polymorphism not only in the duplicated copy but also in its flanking regions, which is a typical signature of a selective sweep by positive selection. After fixation, polymorphism gradually increases by accumulating neutral mutations and eventually reaches the equilibrium value if there is no gene conversion. When gene conversion is active, the number of SNPs in the duplicated copy quickly increases by transferring SNPs from the original copy; therefore, the time when we can recognize the signature of selection is decreased. Because this effect of gene conversion is restricted only to the duplicated region, more power to detect selection is expected if a flanking region to the duplicated copy is used.

Original languageEnglish
Pages (from-to)1077-1086
Number of pages10
JournalGenetics
Volume190
Issue number3
DOIs
Publication statusPublished - Mar 1 2012

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Gene Conversion
Single Nucleotide Polymorphism
Mutation
Genes

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

The coalescent with selection on copy number variants. / Teshima, Kosuke M.; Innan, Hideki.

In: Genetics, Vol. 190, No. 3, 01.03.2012, p. 1077-1086.

Research output: Contribution to journalArticle

Teshima, Kosuke M. ; Innan, Hideki. / The coalescent with selection on copy number variants. In: Genetics. 2012 ; Vol. 190, No. 3. pp. 1077-1086.
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