The Combination of Benzaldehyde and Nickel-Catalyzed Photoredox C(sp 3 )−H Alkylation/Arylation

Lumin Zhang, Xiaojia Si, Yangyang Yang, Marc Zimmer, Sina Witzel, Kohei Sekine, Matthias Rudolph, A. Stephen K. Hashmi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Herein we report a highly selective photoredox C(sp 3 )−H alkylation/arylation of ethers through the combination of a photo-organocatalyst (benzaldehyde) and a transition-metal catalyst (nickel). This method provides a simple and general strategy for the C(sp 3 )−H alkylation/arylation of ethers. A selective late-stage modification of (−)-ambroxide has also been conducted to demonstrate the applicability of the method.

Original languageEnglish
Pages (from-to)1823-1827
Number of pages5
JournalAngewandte Chemie - International Edition
Volume58
Issue number6
DOIs
Publication statusPublished - Feb 4 2019
Externally publishedYes

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Ethers
Alkylation
Nickel
Transition metals
Catalysts
benzaldehyde

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

The Combination of Benzaldehyde and Nickel-Catalyzed Photoredox C(sp 3 )−H Alkylation/Arylation . / Zhang, Lumin; Si, Xiaojia; Yang, Yangyang; Zimmer, Marc; Witzel, Sina; Sekine, Kohei; Rudolph, Matthias; Hashmi, A. Stephen K.

In: Angewandte Chemie - International Edition, Vol. 58, No. 6, 04.02.2019, p. 1823-1827.

Research output: Contribution to journalArticle

Zhang, Lumin ; Si, Xiaojia ; Yang, Yangyang ; Zimmer, Marc ; Witzel, Sina ; Sekine, Kohei ; Rudolph, Matthias ; Hashmi, A. Stephen K. / The Combination of Benzaldehyde and Nickel-Catalyzed Photoredox C(sp 3 )−H Alkylation/Arylation In: Angewandte Chemie - International Edition. 2019 ; Vol. 58, No. 6. pp. 1823-1827.
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