The Combination of Benzaldehyde and Nickel-Catalyzed Photoredox C(sp 3 )−H Alkylation/Arylation

Lumin Zhang, Xiaojia Si, Yangyang Yang, Marc Zimmer, Sina Witzel, Kohei Sekine, Matthias Rudolph, A. Stephen K. Hashmi

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Herein we report a highly selective photoredox C(sp 3 )−H alkylation/arylation of ethers through the combination of a photo-organocatalyst (benzaldehyde) and a transition-metal catalyst (nickel). This method provides a simple and general strategy for the C(sp 3 )−H alkylation/arylation of ethers. A selective late-stage modification of (−)-ambroxide has also been conducted to demonstrate the applicability of the method.

Original languageEnglish
Pages (from-to)1823-1827
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number6
Publication statusPublished - Feb 4 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)


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