The combination of drug or gene delivery system responding to cellular signals (D-RECS) and sonoporation system for effective and safe gene delivery

A. Tsuchiya, T. Mori, Y. Naritomi, J. H. Kang, D. Asai, T. Niidome, Y. Endo, R. Suzuki, Y. Negishi, K. Maruyama, Y. Katayama

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed new gene expression-regulating polymer that can activate transgene expression in response to target intracellular signals. Here, we tried applying sonoporation system to this gene regulation system to enhance the gene expression efficacy. Sonoporation is the method for effective gene transfection in vitro and in vivo. Therefore, the method might enhance the transfection efficiency in our polymer and realize an efficient and safe gene delivery system. Results suggested that the combination of our polymer and sonoporation could improve the gene expression compared to the system using only our polymer that transfers genes into cells via endocytosis. It also kept the ability of the gene regulation responding to cellular signals.

Original languageEnglish
Title of host publicationNanobiotechnology and Nanobiophotonics - Opportunities and Challenges
Pages7-11
Number of pages5
Publication statusPublished - Dec 1 2010
Event2009 MRS Fall Meeting - Boston, MA, United States
Duration: Nov 29 2009Dec 3 2009

Publication series

NameMaterials Research Society Symposium Proceedings
Volume1237
ISSN (Print)0272-9172

Conference

Conference2009 MRS Fall Meeting
CountryUnited States
CityBoston, MA
Period11/29/0912/3/09

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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    Tsuchiya, A., Mori, T., Naritomi, Y., Kang, J. H., Asai, D., Niidome, T., Endo, Y., Suzuki, R., Negishi, Y., Maruyama, K., & Katayama, Y. (2010). The combination of drug or gene delivery system responding to cellular signals (D-RECS) and sonoporation system for effective and safe gene delivery. In Nanobiotechnology and Nanobiophotonics - Opportunities and Challenges (pp. 7-11). (Materials Research Society Symposium Proceedings; Vol. 1237).