The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus

Hitoshi Nakashima; Hisako Inoue; Mitsuteru Akahoshi; Yosuke Tanaka; Kunihiro Yamaoka; Eiichi Ogami; Shuuji Nagano; Yojiro Arinobu; Hiroaki Niiro; Takeshi Otsuka; Yoshiyuki Niho

doi:10.1016/S0014-5793(99)00701-2

The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus

Hitoshi Nakashima, Hisako Inoue, Mitsuteru Akahoshi, Yosuke Tanaka, Kunihiro Yamaoka, Eiichi Ogami, Shuuji Nagano, Yojiro Arinobu, Hiroaki Niiro, Takeshi Otsuka, Yoshiyuki Niho

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Abstract

Genetic factors seem to play a significant role in susceptibility to systemic lupus erythematosus (SLE). We previously described the amino acid polymorphism (Val14Met) within the IFN-γ receptor 1 (IFN-γR1), and that the frequency of the Met14 allele in SLE patients was significantly higher than that of the healthy control population. We also found an amino acid polymorphism (Gln64Arg) within IFN-γ receptor 2 (IFN-γR2). Since the IFN-γ receptor is a complex consisting of IFN-γR1 and IFN-γR2, we searched for the particular combination of two kinds of amino acid polymorphisms found within the IFN-γ receptor which plays a prominent role in susceptibility to SLE. The greatest risk of the development of SLE was detected in the individuals who had the combination of IFNGR1 Met14/Val14 genotype and IFNGR2 Gln64/Gln64 genotype.

Original language	English
Pages (from-to)	187-190
Number of pages	4
Journal	FEBS Letters
Volume	453
Issue number	1-2
DOIs	https://doi.org/10.1016/S0014-5793(99)00701-2
Publication status	Published - Jun 18 1999

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/S0014-5793(99)00701-2

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title = "The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus",

abstract = "Genetic factors seem to play a significant role in susceptibility to systemic lupus erythematosus (SLE). We previously described the amino acid polymorphism (Val14Met) within the IFN-γ receptor 1 (IFN-γR1), and that the frequency of the Met14 allele in SLE patients was significantly higher than that of the healthy control population. We also found an amino acid polymorphism (Gln64Arg) within IFN-γ receptor 2 (IFN-γR2). Since the IFN-γ receptor is a complex consisting of IFN-γR1 and IFN-γR2, we searched for the particular combination of two kinds of amino acid polymorphisms found within the IFN-γ receptor which plays a prominent role in susceptibility to SLE. The greatest risk of the development of SLE was detected in the individuals who had the combination of IFNGR1 Met14/Val14 genotype and IFNGR2 Gln64/Gln64 genotype.",

author = "Hitoshi Nakashima and Hisako Inoue and Mitsuteru Akahoshi and Yosuke Tanaka and Kunihiro Yamaoka and Eiichi Ogami and Shuuji Nagano and Yojiro Arinobu and Hiroaki Niiro and Takeshi Otsuka and Yoshiyuki Niho",

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AU - Nakashima, Hitoshi

AU - Inoue, Hisako

AU - Akahoshi, Mitsuteru

AU - Tanaka, Yosuke

AU - Yamaoka, Kunihiro

AU - Ogami, Eiichi

AU - Nagano, Shuuji

AU - Arinobu, Yojiro

AU - Niiro, Hiroaki

AU - Otsuka, Takeshi

AU - Niho, Yoshiyuki

PY - 1999/6/18

Y1 - 1999/6/18

N2 - Genetic factors seem to play a significant role in susceptibility to systemic lupus erythematosus (SLE). We previously described the amino acid polymorphism (Val14Met) within the IFN-γ receptor 1 (IFN-γR1), and that the frequency of the Met14 allele in SLE patients was significantly higher than that of the healthy control population. We also found an amino acid polymorphism (Gln64Arg) within IFN-γ receptor 2 (IFN-γR2). Since the IFN-γ receptor is a complex consisting of IFN-γR1 and IFN-γR2, we searched for the particular combination of two kinds of amino acid polymorphisms found within the IFN-γ receptor which plays a prominent role in susceptibility to SLE. The greatest risk of the development of SLE was detected in the individuals who had the combination of IFNGR1 Met14/Val14 genotype and IFNGR2 Gln64/Gln64 genotype.

AB - Genetic factors seem to play a significant role in susceptibility to systemic lupus erythematosus (SLE). We previously described the amino acid polymorphism (Val14Met) within the IFN-γ receptor 1 (IFN-γR1), and that the frequency of the Met14 allele in SLE patients was significantly higher than that of the healthy control population. We also found an amino acid polymorphism (Gln64Arg) within IFN-γ receptor 2 (IFN-γR2). Since the IFN-γ receptor is a complex consisting of IFN-γR1 and IFN-γR2, we searched for the particular combination of two kinds of amino acid polymorphisms found within the IFN-γ receptor which plays a prominent role in susceptibility to SLE. The greatest risk of the development of SLE was detected in the individuals who had the combination of IFNGR1 Met14/Val14 genotype and IFNGR2 Gln64/Gln64 genotype.

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ER -

The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus

Abstract

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