The complex cartography of stem cell commitment

Koichi Akashi, David Traver, Leonard I. Zon

Research output: Contribution to journalShort survey

27 Citations (Scopus)

Abstract

In this issue of Cell, a study by Adolfsson and coworkers (Adolfsson et al., 2005) provides insight into the early lineage commitment events of multipotent hematopoietic stem cells (HSCs). These studies demonstrate the importance of the Flt3 receptor tyrosine kinase as the earliest marker of hematopoietic cell fate commitment in that erythrocyte and megakaryocyte potentials are lost first as HSCs differentiate to lymphocyte progenitors.

Original languageEnglish
Pages (from-to)160-162
Number of pages3
JournalCell
Volume121
Issue number2
DOIs
Publication statusPublished - Apr 22 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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