[The concept and history of biomarker].

Ryoji Nonaka, Junichi Nishimura, Masaki Mori

Research output: Contribution to journalReview article

Abstract

Biomarker is a characteristic objectively measured and an indicator of biological process. This term indicates not only biological substance, for example protein, ribonucleic acid but also imaging assays. Disease biomarkers have been applied to a wide variety of clinical areas, including oncology, metabolic disorders, neurological disease and immune dysregulation. In recent years because of the progress of analysis technology, new biomarkers continue to be devised and used as diagnostic, predictive, prognostic, and toxic marker. In drug development area, biomarkers are used as surrogate endpoint to substitute for a clinical endpoint and needed for rational drug development. Here, we summarize the concept and history of biomarker.

Original languageEnglish
Pages (from-to)737-742
Number of pages6
JournalNihon rinsho. Japanese journal of clinical medicine
Volume70
Issue number5
Publication statusPublished - May 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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