The conjunctive stimuli that cause long-term desensitization also predominantly induce c-fos and jun-B in cerebellar purkinje cells

Kazutoshi Nakazawa, Laddawan Karachot, Yusaku Nakabeppu, Tetsuo Yamamori

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Expression of immediate early genes (IEGs) was examined following long-term desensitization of cerebellar Purkinje cells. This form of desensitization, which may underlie synaptic long-term depression (LTD), was evoked by co-administration of a-amino-3-hydroxy-5- methyl-4-isoxazole-propionate (AMPA) and 8-bromo cGMP (8-Br-cGMP). Among the IEGS examined with in situ hybridization and immunohistochemistry, combined application of 8-Br-cGMP and AMPA synergistically enhanced the expression of c-Fos and Jun-B in Purkinje cells. This may suggest a role for active transcriptional complexes such as AP-1 (c-Fos/Jun-B), which could be formed following conjoint inputs to Purkinje cells and which may help to establish cerebellar long-term plasticity.

Original languageEnglish
Pages (from-to)1275-1278
Number of pages4
JournalNeuroReport
Volume4
Issue number11
DOIs
Publication statusPublished - Sep 10 1993

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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