The conjunctive stimuli that cause long-term desensitization also predominantly induce c-fos and jun-B in cerebellar purkinje cells

Kazutoshi Nakazawa, Laddawan Karachot, Yusaku Nakabeppu, Tetsuo Yamamori

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Expression of immediate early genes (IEGs) was examined following long-term desensitization of cerebellar Purkinje cells. This form of desensitization, which may underlie synaptic long-term depression (LTD), was evoked by co-administration of a-amino-3-hydroxy-5- methyl-4-isoxazole-propionate (AMPA) and 8-bromo cGMP (8-Br-cGMP). Among the IEGS examined with in situ hybridization and immunohistochemistry, combined application of 8-Br-cGMP and AMPA synergistically enhanced the expression of c-Fos and Jun-B in Purkinje cells. This may suggest a role for active transcriptional complexes such as AP-1 (c-Fos/Jun-B), which could be formed following conjoint inputs to Purkinje cells and which may help to establish cerebellar long-term plasticity.

Original languageEnglish
Pages (from-to)1275-1278
Number of pages4
JournalNeuroReport
Volume4
Issue number11
DOIs
Publication statusPublished - Sep 10 1993

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Purkinje Cells
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Long-Term Synaptic Depression
Isoxazoles
Immediate-Early Genes
Transcription Factor AP-1
Propionates
In Situ Hybridization
Immunohistochemistry
8-bromocyclic GMP

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

The conjunctive stimuli that cause long-term desensitization also predominantly induce c-fos and jun-B in cerebellar purkinje cells. / Nakazawa, Kazutoshi; Karachot, Laddawan; Nakabeppu, Yusaku; Yamamori, Tetsuo.

In: NeuroReport, Vol. 4, No. 11, 10.09.1993, p. 1275-1278.

Research output: Contribution to journalArticle

Nakazawa, Kazutoshi ; Karachot, Laddawan ; Nakabeppu, Yusaku ; Yamamori, Tetsuo. / The conjunctive stimuli that cause long-term desensitization also predominantly induce c-fos and jun-B in cerebellar purkinje cells. In: NeuroReport. 1993 ; Vol. 4, No. 11. pp. 1275-1278.
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