The correlation between the telomeric parameters and the clinical laboratory data in the patients with brain infarct and metabolic disorders

Toyoki Maeda, J. I. Oyama, Yoshihiro Higuchi, T. Arima, Koshi Mimori, N. Makino

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3 Citations (Scopus)

Abstract

Objective: To elucidate the correlation between the telomere length and subtelomeric methylated status in peripheral leukocytes and the laboratory data of inpatients with brain infarction and metabolic disorders. This is the first report describing a link between routine clinical laboratory data and genomic aging. Design: Cross-sectional population-based study. Setting: Chronic disease ward of Kyushu University Hospital at Beppu in Japan. Participants: Inpatients with brain infarction and metabolic disorders. Measurements: The laboratory data of male patients were collected and the telomeric parameters in their peripheral leukocytes were determined by a Southern blot analysis with methylation-sensitive and insensitive isoschizomers. Any correlations between the laboratory data and the telomeric parameters were assessed. Results: The patients revealed a significant correlation among the fasting blood sugar, HbA1c, serum creatinine and urea nitrogen levels with the mean telomere length, expression of long telomeres (>9.4 kb), or the subtelomeric hypermethylation status of long telomeres. Conclusion: Our results suggested that the hyperglycemia and renal function of patients with metabolic disorders correlated positively with the aging-associated telomeric changes.

Original languageEnglish
Pages (from-to)793-797
Number of pages5
JournalJournal of Nutrition, Health and Aging
Volume14
Issue number9
DOIs
Publication statusPublished - Nov 1 2010

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Metabolic Brain Diseases
Telomere
Brain Infarction
Inpatients
Leukocytes
Southern Blotting
Hyperglycemia
Methylation
Blood Glucose
Urea
Fasting
Creatinine
Japan
Chronic Disease
Nitrogen
Kidney
Serum
Population

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Geriatrics and Gerontology

Cite this

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abstract = "Objective: To elucidate the correlation between the telomere length and subtelomeric methylated status in peripheral leukocytes and the laboratory data of inpatients with brain infarction and metabolic disorders. This is the first report describing a link between routine clinical laboratory data and genomic aging. Design: Cross-sectional population-based study. Setting: Chronic disease ward of Kyushu University Hospital at Beppu in Japan. Participants: Inpatients with brain infarction and metabolic disorders. Measurements: The laboratory data of male patients were collected and the telomeric parameters in their peripheral leukocytes were determined by a Southern blot analysis with methylation-sensitive and insensitive isoschizomers. Any correlations between the laboratory data and the telomeric parameters were assessed. Results: The patients revealed a significant correlation among the fasting blood sugar, HbA1c, serum creatinine and urea nitrogen levels with the mean telomere length, expression of long telomeres (>9.4 kb), or the subtelomeric hypermethylation status of long telomeres. Conclusion: Our results suggested that the hyperglycemia and renal function of patients with metabolic disorders correlated positively with the aging-associated telomeric changes.",
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T1 - The correlation between the telomeric parameters and the clinical laboratory data in the patients with brain infarct and metabolic disorders

AU - Maeda, Toyoki

AU - Oyama, J. I.

AU - Higuchi, Yoshihiro

AU - Arima, T.

AU - Mimori, Koshi

AU - Makino, N.

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Objective: To elucidate the correlation between the telomere length and subtelomeric methylated status in peripheral leukocytes and the laboratory data of inpatients with brain infarction and metabolic disorders. This is the first report describing a link between routine clinical laboratory data and genomic aging. Design: Cross-sectional population-based study. Setting: Chronic disease ward of Kyushu University Hospital at Beppu in Japan. Participants: Inpatients with brain infarction and metabolic disorders. Measurements: The laboratory data of male patients were collected and the telomeric parameters in their peripheral leukocytes were determined by a Southern blot analysis with methylation-sensitive and insensitive isoschizomers. Any correlations between the laboratory data and the telomeric parameters were assessed. Results: The patients revealed a significant correlation among the fasting blood sugar, HbA1c, serum creatinine and urea nitrogen levels with the mean telomere length, expression of long telomeres (>9.4 kb), or the subtelomeric hypermethylation status of long telomeres. Conclusion: Our results suggested that the hyperglycemia and renal function of patients with metabolic disorders correlated positively with the aging-associated telomeric changes.

AB - Objective: To elucidate the correlation between the telomere length and subtelomeric methylated status in peripheral leukocytes and the laboratory data of inpatients with brain infarction and metabolic disorders. This is the first report describing a link between routine clinical laboratory data and genomic aging. Design: Cross-sectional population-based study. Setting: Chronic disease ward of Kyushu University Hospital at Beppu in Japan. Participants: Inpatients with brain infarction and metabolic disorders. Measurements: The laboratory data of male patients were collected and the telomeric parameters in their peripheral leukocytes were determined by a Southern blot analysis with methylation-sensitive and insensitive isoschizomers. Any correlations between the laboratory data and the telomeric parameters were assessed. Results: The patients revealed a significant correlation among the fasting blood sugar, HbA1c, serum creatinine and urea nitrogen levels with the mean telomere length, expression of long telomeres (>9.4 kb), or the subtelomeric hypermethylation status of long telomeres. Conclusion: Our results suggested that the hyperglycemia and renal function of patients with metabolic disorders correlated positively with the aging-associated telomeric changes.

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