The design of antimicrobial peptides based on the novel concept

Yoshinao Yamada, Yoshiko Miura, Kazukiyo Kobayashi

Research output: Contribution to conferencePaper

Abstract

Recently, we have developed a new type of antimicrobial peptides based on nuclear localization signal (NLS) sequences. We also have found that a globotriaosyl (Gb3) mimic peptide bound Shiga toxins strongly and neutralized the toxins effectively. The present paper proposes the design of tandem fusion peptides between NLS peptides and Gb3 mimic peptides. The tandem fusion peptides expressed multifunctions of both antimicrobial and Stx neutralization activities. The antimicrobial activity of the NLS peptide has been strongly enhanced by combining the Gb3 mimic sequence to its N-terminal. This proposed fusion peptides are expected to destroy bacteria and neutralize the released toxins simultaneously.

Original languageEnglish
Pages4859-4860
Number of pages2
Publication statusPublished - Dec 1 2005
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: Sep 20 2005Sep 22 2005

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period9/20/059/22/05

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Peptides
Fusion reactions
Bacteria
Protein Sorting Signals

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Yamada, Y., Miura, Y., & Kobayashi, K. (2005). The design of antimicrobial peptides based on the novel concept. 4859-4860. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.

The design of antimicrobial peptides based on the novel concept. / Yamada, Yoshinao; Miura, Yoshiko; Kobayashi, Kazukiyo.

2005. 4859-4860 Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.

Research output: Contribution to conferencePaper

Yamada, Y, Miura, Y & Kobayashi, K 2005, 'The design of antimicrobial peptides based on the novel concept' Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan, 9/20/05 - 9/22/05, pp. 4859-4860.
Yamada Y, Miura Y, Kobayashi K. The design of antimicrobial peptides based on the novel concept. 2005. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.
Yamada, Yoshinao ; Miura, Yoshiko ; Kobayashi, Kazukiyo. / The design of antimicrobial peptides based on the novel concept. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.2 p.
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