Abstract
Oxidative stress is caused by increased reactive-oxygen species (ROS) due to augmented ROS production and impaired anti-oxidative capacity. Recently, oxidative stress has been revealed to promote castration resistance via androgen receptor(AR)-dependent pathway such as AR overexpression, AR cofactor, and AR post-translational modification as well as AR-independent pathway, leading to the emergence of castration-resistant prostate cancer (CRPC). Therefore, antioxidants therapy using natural and chemical ROS scavengers and inhibitors of ROS production seems to be a promising therapy for CRPC as well as preventing castration resistance. However, at present, the application to therapeutics is limited. Therefore, further research on oxidative stress in prostate cancer, as well as on the development for clinical application would be needed.
| Original language | English |
|---|---|
| Pages (from-to) | 2131-2135 |
| Number of pages | 5 |
| Journal | Nihon rinsho. Japanese journal of clinical medicine |
| Volume | 72 |
| Issue number | 12 |
| Publication status | Published - Dec 1 2014 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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[The development of therapeutics targeting oxidative stress in prostate cancer]. / Shiota, Masaki; Yokomizo, Akira; Naito, Seiji.
In: Nihon rinsho. Japanese journal of clinical medicine, Vol. 72, No. 12, 01.12.2014, p. 2131-2135.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - [The development of therapeutics targeting oxidative stress in prostate cancer]
AU - Shiota, Masaki
AU - Yokomizo, Akira
AU - Naito, Seiji
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Oxidative stress is caused by increased reactive-oxygen species (ROS) due to augmented ROS production and impaired anti-oxidative capacity. Recently, oxidative stress has been revealed to promote castration resistance via androgen receptor(AR)-dependent pathway such as AR overexpression, AR cofactor, and AR post-translational modification as well as AR-independent pathway, leading to the emergence of castration-resistant prostate cancer (CRPC). Therefore, antioxidants therapy using natural and chemical ROS scavengers and inhibitors of ROS production seems to be a promising therapy for CRPC as well as preventing castration resistance. However, at present, the application to therapeutics is limited. Therefore, further research on oxidative stress in prostate cancer, as well as on the development for clinical application would be needed.
AB - Oxidative stress is caused by increased reactive-oxygen species (ROS) due to augmented ROS production and impaired anti-oxidative capacity. Recently, oxidative stress has been revealed to promote castration resistance via androgen receptor(AR)-dependent pathway such as AR overexpression, AR cofactor, and AR post-translational modification as well as AR-independent pathway, leading to the emergence of castration-resistant prostate cancer (CRPC). Therefore, antioxidants therapy using natural and chemical ROS scavengers and inhibitors of ROS production seems to be a promising therapy for CRPC as well as preventing castration resistance. However, at present, the application to therapeutics is limited. Therefore, further research on oxidative stress in prostate cancer, as well as on the development for clinical application would be needed.
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UR - http://www.scopus.com/inward/citedby.url?scp=84922230292&partnerID=8YFLogxK
M3 - Article
C2 - 25518346
AN - SCOPUS:84922230292
VL - 72
SP - 2131
EP - 2135
JO - Astrophysical Journal
JF - Astrophysical Journal
SN - 0004-637X
IS - 12
ER -