[The difference between male and female dioxin concentrations in the blood of Yusho patients].

Jumboku Kajiwara, Takashi Todaka, Hironori Hirakawa, Tsuguhide Hori, Daisuke Onozuka, Yoshiko Takao, Teruaki Hirata, Takao Iida, Hiroshi Uchi, Masutaka Furue

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3 Citations (Scopus)

Abstract

In 1968, the contamination of cooking oil by heat-degraded polychlorinated biphenyls (PCBs) caused a case of mass poisoning, the so-called Yusho incident. The cause of Yusho disease is thought to be ingested toxic substances, including not only PCBs but polychlorinated dibenzofuran (PCDFs) in Kanemi rice oil. Extensive studies have been performed since 1995 by the Yusho study group involving follow-up surveys of human blood concentrations of the casual compounds in Yusho patients as well as clinical trials of the acceleration of the excretion of these compounds in Yusho patients. We have previously measured dioxin concentrations in the blood of 649 Yusho patients in annual medical examinations from 2001 to 2009. We determined that the concentrations of 2,3,4,7,8-PeCDF 1,2,3,4,7,8-HxCDF 1,2,3,6,7,8-HxCDF, and 3,3',4,4',5,5'-HxCB (#169) in the blood of Yusho patients were more than twice as high levels to as those of normal controls. In this study, we compared the concentrations of 2,3,4,7,8-PeCDF, 1,2,3,4,7,8-HxCDF, 1,2,3,6,7,8-HxCDF, and 3,3',4,4',5,5'-HxCB (#169) in the blood of male Yusho patients with those of female Yusho patients. As a result, it was found that the mean concentrations of 2,3,4,7,8-PeCDF 1,2,3,4, 7,8-HxCDF 1,2,3,6,7,8-HxCDF, and 3,3',4,4',5,5'-HxCB (#169) in female Yusho patients were 2.9, 3.7, 2.4, and 1.3 times higher, respectively, than those of male Yusho patients.

Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume102
Issue number4
Publication statusPublished - Apr 1 2011

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Kajiwara, J., Todaka, T., Hirakawa, H., Hori, T., Onozuka, D., Takao, Y., Hirata, T., Iida, T., Uchi, H., & Furue, M. (2011). [The difference between male and female dioxin concentrations in the blood of Yusho patients]. Fukuoka igaku zasshi = Hukuoka acta medica, 102(4), 140-144.