The differential coupling of oxytocin receptors to uterine contractions in murine estrous cycle

Masaki Kawamata, Yutaka Tonomura, Tadashi Kimura, Teruyuki Yanagisawa, Katsuhiko Nishimori

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Oxytocin (OT)-induced uterine contractility in different ovulatory phases has not been characterized in mouse. While the uterus was refractory to OT at diestrous phase, numerous contractions were observed at estrous phase. The magnitude of uterine contractile response to OT at estrous phase was larger than that at diestrous phase. There was also significant difference in the pD 2 values for OT between the samples from the two phases. However, the level of OT receptor (OTR) transcripts and proteins was equivalent at the two phases. These results suggest that OT-induced uterine contraction is not only regulated by the quantity of OTR in the non-pregnant mouse uterus.

Original languageEnglish
Pages (from-to)695-699
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume321
Issue number3
DOIs
Publication statusPublished - Aug 27 2004

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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