The Distribution of Dioxin Concentrations in the Blood of Yusho Patients

Jumboku Kajiwara, Takashi Todaka, Hironori Hirakawa, Tsuguhide Hori, Teruaki Hirata, Takao Iida, Hiroshi Uchi, Masutaka Furue

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Abstract

In 1968, the contamination of cooking oil by heat-degraded polychlorinated biphenyls (PCBs) caused a case of mass poisoning, the so-called Yusho incident. The cause of Yusho disease is thought to be ingested toxic substances, including not only PCBs but also polychlorinated dibenzofuran (PCDFs) in Kanemi rice oil. We previously measured dioxins concentrations in the blood of 854 Yusho patients by annual medical examination from 2001 to 2013. We determined the concentrations of 2,3,4,7,8-PeCDF, 1,2,3,4,7,8-HxCDF, 1,2,3,6,7,8-HxCDF and 3,3',4,4',5,5'-HxCB (#169) in the blood of Yusho patients were more than double those of normal controls. In 2012, a new Yusho criteria was established. Family members living with a Yusho patient were also certified as Yusho patients and called Yusho family cohabitant patients. In this study, we compared the distribution of 2,3,4,7,8-PeCDF concentration in the blood of Yusho patients and Yusho family cohabitant patients. It was suspected that the distribution of 2,3,4,7,8-PeCDF concentration in Yusho family cohabitant patients would be lower than that of Yusho patients.

Original languageEnglish
Pages (from-to)149-153
Number of pages5
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume106
Issue number5
Publication statusPublished - May 1 2015

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Kajiwara, J., Todaka, T., Hirakawa, H., Hori, T., Hirata, T., Iida, T., Uchi, H., & Furue, M. (2015). The Distribution of Dioxin Concentrations in the Blood of Yusho Patients. Fukuoka igaku zasshi = Hukuoka acta medica, 106(5), 149-153.