The distribution of fibronectin and laminin in the murine periodontal membrane, indicating possible functional roles in the apical migration of the junctional epithelium

Takako Sakai, Yasuyoshi Ohsaki, Mizuho Kido, Mieko Goto, Yoshihiro Terada, Hidetaka Sakai

Research output: Contribution to journalArticle

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Abstract

Periodontal tissue shows various morphological changes with ageing. A typical example of these changes is the apical migration of the junctional epithelium. The distribution of fibronectin and laminin was investigated by immunofluorescent and immunoelectron-microscope methods in mice to clarify any possible functional roles of these proteins in the apical migration of junctional epithelium. Apical migration begins in 20-week-old mice, and then progresses with increasing age until the mice reach 80 weeks. In the apical tip of the junctional epithelium, fibronectin was demonstrated in the subepithelial fibrillar matrix, preceding the progression of apical migration. Fibronectin was also demonstrated in association with the stromal side of focal contacts between epithelial cells and basement membrane. Therefore, these focal contacts are assumed to be fibronectin receptors. There was no apparent relation between the localization of laminin and the migration of the junctional epithelium. These results suggest that the fibronectin provides a provisional matrix for the apical migration of junctional epithelium, but laminin does not appear to play a major part in that migration.

Original languageEnglish
Pages (from-to)885-891
Number of pages7
JournalArchives of Oral Biology
Volume41
Issue number8-9
DOIs
Publication statusPublished - Aug 1 1996

Fingerprint

Epithelial Attachment
Laminin
Fibronectins
Membranes
Focal Adhesions
Fibronectin Receptors
Basement Membrane
Epithelial Cells
Cell Membrane
Proteins

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

Cite this

The distribution of fibronectin and laminin in the murine periodontal membrane, indicating possible functional roles in the apical migration of the junctional epithelium. / Sakai, Takako; Ohsaki, Yasuyoshi; Kido, Mizuho; Goto, Mieko; Terada, Yoshihiro; Sakai, Hidetaka.

In: Archives of Oral Biology, Vol. 41, No. 8-9, 01.08.1996, p. 885-891.

Research output: Contribution to journalArticle

Sakai, Takako ; Ohsaki, Yasuyoshi ; Kido, Mizuho ; Goto, Mieko ; Terada, Yoshihiro ; Sakai, Hidetaka. / The distribution of fibronectin and laminin in the murine periodontal membrane, indicating possible functional roles in the apical migration of the junctional epithelium. In: Archives of Oral Biology. 1996 ; Vol. 41, No. 8-9. pp. 885-891.
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