Abstract
Periodontal tissue shows various morphological changes with ageing. A typical example of these changes is the apical migration of the junctional epithelium. The distribution of fibronectin and laminin was investigated by immunofluorescent and immunoelectron-microscope methods in mice to clarify any possible functional roles of these proteins in the apical migration of junctional epithelium. Apical migration begins in 20-week-old mice, and then progresses with increasing age until the mice reach 80 weeks. In the apical tip of the junctional epithelium, fibronectin was demonstrated in the subepithelial fibrillar matrix, preceding the progression of apical migration. Fibronectin was also demonstrated in association with the stromal side of focal contacts between epithelial cells and basement membrane. Therefore, these focal contacts are assumed to be fibronectin receptors. There was no apparent relation between the localization of laminin and the migration of the junctional epithelium. These results suggest that the fibronectin provides a provisional matrix for the apical migration of junctional epithelium, but laminin does not appear to play a major part in that migration.
| Original language | English |
|---|---|
| Pages (from-to) | 885-891 |
| Number of pages | 7 |
| Journal | Archives of Oral Biology |
| Volume | 41 |
| Issue number | 8-9 |
| DOIs | |
| Publication status | Published - Aug 1 1996 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Otorhinolaryngology
- Dentistry(all)
- Cell Biology
Cite this
The distribution of fibronectin and laminin in the murine periodontal membrane, indicating possible functional roles in the apical migration of the junctional epithelium. / Sakai, Takako; Ohsaki, Yasuyoshi; Kido, Mizuho; Goto, Mieko; Terada, Yoshihiro; Sakai, Hidetaka.
In: Archives of Oral Biology, Vol. 41, No. 8-9, 01.08.1996, p. 885-891.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The distribution of fibronectin and laminin in the murine periodontal membrane, indicating possible functional roles in the apical migration of the junctional epithelium
AU - Sakai, Takako
AU - Ohsaki, Yasuyoshi
AU - Kido, Mizuho
AU - Goto, Mieko
AU - Terada, Yoshihiro
AU - Sakai, Hidetaka
PY - 1996/8/1
Y1 - 1996/8/1
N2 - Periodontal tissue shows various morphological changes with ageing. A typical example of these changes is the apical migration of the junctional epithelium. The distribution of fibronectin and laminin was investigated by immunofluorescent and immunoelectron-microscope methods in mice to clarify any possible functional roles of these proteins in the apical migration of junctional epithelium. Apical migration begins in 20-week-old mice, and then progresses with increasing age until the mice reach 80 weeks. In the apical tip of the junctional epithelium, fibronectin was demonstrated in the subepithelial fibrillar matrix, preceding the progression of apical migration. Fibronectin was also demonstrated in association with the stromal side of focal contacts between epithelial cells and basement membrane. Therefore, these focal contacts are assumed to be fibronectin receptors. There was no apparent relation between the localization of laminin and the migration of the junctional epithelium. These results suggest that the fibronectin provides a provisional matrix for the apical migration of junctional epithelium, but laminin does not appear to play a major part in that migration.
AB - Periodontal tissue shows various morphological changes with ageing. A typical example of these changes is the apical migration of the junctional epithelium. The distribution of fibronectin and laminin was investigated by immunofluorescent and immunoelectron-microscope methods in mice to clarify any possible functional roles of these proteins in the apical migration of junctional epithelium. Apical migration begins in 20-week-old mice, and then progresses with increasing age until the mice reach 80 weeks. In the apical tip of the junctional epithelium, fibronectin was demonstrated in the subepithelial fibrillar matrix, preceding the progression of apical migration. Fibronectin was also demonstrated in association with the stromal side of focal contacts between epithelial cells and basement membrane. Therefore, these focal contacts are assumed to be fibronectin receptors. There was no apparent relation between the localization of laminin and the migration of the junctional epithelium. These results suggest that the fibronectin provides a provisional matrix for the apical migration of junctional epithelium, but laminin does not appear to play a major part in that migration.
UR - http://www.scopus.com/inward/record.url?scp=0030210510&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030210510&partnerID=8YFLogxK
U2 - 10.1016/S0003-9969(96)00014-3
DO - 10.1016/S0003-9969(96)00014-3
M3 - Article
C2 - 9022926
AN - SCOPUS:0030210510
VL - 41
SP - 885
EP - 891
JO - Archives of Oral Biology
JF - Archives of Oral Biology
SN - 0003-9969
IS - 8-9
ER -