The dopamine D 1 receptor agonist, but not the D 2 receptor agonist, induces gene expression of Homer 1a in rat striatum and nucleus accumbens

Hidetaka Yamada, Toshihide Kuroki, Tatsuo Nakahara, Kijiro Hashimoto, Tetsuyuki Tsutsumi, Makoto Hirano, Hisao Maeda

Research output: Contribution to journalArticle

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Abstract

Stimulation of dopamine receptors may induce striatal Homer 1a, an immediate-early gene (IEG) that is involved in the molecular mechanism for the signaling pathway of the group I metabotropic glutamate receptors. This study examined the effects of the agonists for dopamine D 1 -like and D 2 -like receptors on gene expression of Homer 1a, in comparison with the IEG c-fos expression, in the discrete brain regions of rats. The D 1 -like agonist SKF38393 (20 mg/kg, s.c.) significantly increased the mRNA levels of Homer 1a in the striatum and nucleus accumbens, but not in the medial prefrontal cortex or hippocampus, 2 h after injection, whereas the D 2 -like agonist quinpirole (1 mg/kg, s.c.) had no significant effect on Homer 1a mRNA levels in any brain region examined. Co-administration of SKF38393 and quinpirole significantly increased Homer 1a mRNA levels in the striatum, nucleus accumbens and hippocampus, while this effect was not significantly greater than that of SKF38393 alone. Any treatment did not affect the mRNA levels of other splicing variants, Homer 1b or 1c. In contrast, combination of both dopamine agonists produced a greater increase than SKF38393 did in the mRNA levels of c-fos in the nucleus accumbens, striatum and substantia nigra. These results suggest that stimulation of D 1 -like receptors, but not D 2 -like receptors, may induce gene expression of Homer 1a in the striatum and nucleus accumbens. However, in contrast to c-fos expression, it is unlikely that co-activation of both D 1 -like and D 2 -like receptors exerts a synergic action on Homer 1a expression in these regions.

Original languageEnglish
Pages (from-to)88-96
Number of pages9
JournalBrain Research
Volume1131
Issue number1
DOIs
Publication statusPublished - Feb 2 2007

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Nucleus Accumbens
Dopamine
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Gene Expression
Messenger RNA
Quinpirole
Immediate-Early Genes
Dopamine Agonists
Hippocampus
Corpus Striatum
Metabotropic Glutamate Receptors
Dopamine Receptors
Brain
Substantia Nigra
Homer Scaffolding Proteins
Prefrontal Cortex
Injections

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

The dopamine D 1 receptor agonist, but not the D 2 receptor agonist, induces gene expression of Homer 1a in rat striatum and nucleus accumbens . / Yamada, Hidetaka; Kuroki, Toshihide; Nakahara, Tatsuo; Hashimoto, Kijiro; Tsutsumi, Tetsuyuki; Hirano, Makoto; Maeda, Hisao.

In: Brain Research, Vol. 1131, No. 1, 02.02.2007, p. 88-96.

Research output: Contribution to journalArticle

Yamada, Hidetaka ; Kuroki, Toshihide ; Nakahara, Tatsuo ; Hashimoto, Kijiro ; Tsutsumi, Tetsuyuki ; Hirano, Makoto ; Maeda, Hisao. / The dopamine D 1 receptor agonist, but not the D 2 receptor agonist, induces gene expression of Homer 1a in rat striatum and nucleus accumbens In: Brain Research. 2007 ; Vol. 1131, No. 1. pp. 88-96.
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