TY - JOUR
T1 - The dorsal aorta initiates a molecular cascade that instructs sympatho-adrenal specification
AU - Saito, Daisuke
AU - Takase, Yuta
AU - Murai, Hidetaka
AU - Takahashi, Yoshiko
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2012/6/22
Y1 - 2012/6/22
N2 - The autonomic nervous system, which includes the sympathetic neurons and adrenal medulla, originates from the neural crest. Combining avian blood vessel-specific gene manipulation and mouse genetics, we addressed a long-standing question of how neural crest cells (NCCs) generate sympathetic and medullary lineages during embryogenesis. We found that the dorsal aorta acts as a morphogenetic signaling center that coordinates NCC migration and cell lineage segregation. Bone morphogenetic proteins (BMPs) produced by the dorsal aorta are critical for the production of the chemokine stromal cell-derived factor-1 (SDF 1) and Neuregulin 1 in the para-aortic region, which act as chemoattractants for early migration. Later, BMP signaling is directly involved in the sympatho-medullary segregation. This study provides insights into the complex developmental signaling cascade that instructs one of the earliest events of neurovascular interactions guiding embryonic development.
AB - The autonomic nervous system, which includes the sympathetic neurons and adrenal medulla, originates from the neural crest. Combining avian blood vessel-specific gene manipulation and mouse genetics, we addressed a long-standing question of how neural crest cells (NCCs) generate sympathetic and medullary lineages during embryogenesis. We found that the dorsal aorta acts as a morphogenetic signaling center that coordinates NCC migration and cell lineage segregation. Bone morphogenetic proteins (BMPs) produced by the dorsal aorta are critical for the production of the chemokine stromal cell-derived factor-1 (SDF 1) and Neuregulin 1 in the para-aortic region, which act as chemoattractants for early migration. Later, BMP signaling is directly involved in the sympatho-medullary segregation. This study provides insights into the complex developmental signaling cascade that instructs one of the earliest events of neurovascular interactions guiding embryonic development.
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U2 - 10.1126/science.1222369
DO - 10.1126/science.1222369
M3 - Article
C2 - 22723422
AN - SCOPUS:84862589681
VL - 336
SP - 1578
EP - 1581
JO - Science
JF - Science
SN - 0036-8075
IS - 6088
ER -