The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors

Kenichi Horisawa, Miyako Udono, Kazuko Ueno, Yasuyuki Ohkawa, Masao Nagasaki, Sayaka Sekiya, Atsushi Suzuki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

During the direct reprogramming of fibroblasts to hepatocyte-like cells, Foxa3 acts as a pioneer factor, similar to Foxa1 and Foxa2, but leaves its binding site to interact and migrate with RNA polymerase II, thereby inducing the transcription of target genes.

Original languageEnglish
Pages (from-to)660-676.e8
JournalMolecular Cell
Volume79
Issue number4
DOIs
Publication statusPublished - Aug 20 2020

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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