The effect of a herbal medicine (Mao-to) for the prevention of interferon-induced psychiatric complications in chronic hepatitis C: A pilot study

Mosaburo Kainuma, Hiroaki Hikiami, Kazuya Nozaki, Katsumi Hayashi, Yutaka Shimada, Katsutoshi Terasawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective. To evaluate the efficacy of a herbal medicine (Mao-to) on psychiatric complications caused by IFN, and to examine the relationship between depression and microcirculation. Methods. Twelve patients with chronic hepatitis C and a past history of IFN-induced depression were enrolled in this study. Their mental state was evaluated by the self-rating depression scale (SDS) ≧40, or M-R of the Cornell medical index (CMI) ≧10. Each patient received a daily dose of 6 million units of IFN-β for 8 weeks, and Mao-to was given orally four times a day during the IFN-β course. Results. All patients in this study completed a full course of IFN. Mean CMI scores (M-R) had significantly decreased at the end of the treatment. Mean erythrocyte aggregability and erythrocyte deformability had also significantly decreased at the end of treatment. Conclusion. Mao-to might be useful for preventing the incidence of depression in patients with chronic hepatitis C being treated with IFN. The mechanism by which Mao-to prevents depression is suggested to be through the improvement of microcirculation.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
JournalHuman Psychopharmacology
Volume19
Issue number4
DOIs
Publication statusPublished - Jun 1 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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