The effect of a herbal medicine (Mao-to) for the prevention of interferon-induced psychiatric complications in chronic hepatitis C: A pilot study

Mosaburo Kainuma, Hiroaki Hikiami, Kazuya Nozaki, Katsumi Hayashi, Yutaka Shimada, Katsutoshi Terasawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective. To evaluate the efficacy of a herbal medicine (Mao-to) on psychiatric complications caused by IFN, and to examine the relationship between depression and microcirculation. Methods. Twelve patients with chronic hepatitis C and a past history of IFN-induced depression were enrolled in this study. Their mental state was evaluated by the self-rating depression scale (SDS) ≧40, or M-R of the Cornell medical index (CMI) ≧10. Each patient received a daily dose of 6 million units of IFN-β for 8 weeks, and Mao-to was given orally four times a day during the IFN-β course. Results. All patients in this study completed a full course of IFN. Mean CMI scores (M-R) had significantly decreased at the end of the treatment. Mean erythrocyte aggregability and erythrocyte deformability had also significantly decreased at the end of treatment. Conclusion. Mao-to might be useful for preventing the incidence of depression in patients with chronic hepatitis C being treated with IFN. The mechanism by which Mao-to prevents depression is suggested to be through the improvement of microcirculation.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
JournalHuman Psychopharmacology
Volume19
Issue number4
DOIs
Publication statusPublished - Jun 1 2004
Externally publishedYes

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Herbal Medicine
Chronic Hepatitis C
Interferons
Psychiatry
Cornell Medical Index
Microcirculation
Erythrocyte Deformability
Erythrocytes
Mao-to
Incidence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

The effect of a herbal medicine (Mao-to) for the prevention of interferon-induced psychiatric complications in chronic hepatitis C : A pilot study. / Kainuma, Mosaburo; Hikiami, Hiroaki; Nozaki, Kazuya; Hayashi, Katsumi; Shimada, Yutaka; Terasawa, Katsutoshi.

In: Human Psychopharmacology, Vol. 19, No. 4, 01.06.2004, p. 235-241.

Research output: Contribution to journalArticle

Kainuma, Mosaburo ; Hikiami, Hiroaki ; Nozaki, Kazuya ; Hayashi, Katsumi ; Shimada, Yutaka ; Terasawa, Katsutoshi. / The effect of a herbal medicine (Mao-to) for the prevention of interferon-induced psychiatric complications in chronic hepatitis C : A pilot study. In: Human Psychopharmacology. 2004 ; Vol. 19, No. 4. pp. 235-241.
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