TY - JOUR
T1 - The effect of duration of illness and antipsychotics on subcortical volumes in schizophrenia
T2 - Analysis of 778 subjects
AU - COCORO
AU - Hashimoto, Naoki
AU - Ito, Yoichi M.
AU - Okada, Naohiro
AU - Yamamori, Hidenaga
AU - Yasuda, Yuka
AU - Fujimoto, Michiko
AU - Kudo, Noriko
AU - Takemura, Ariyoshi
AU - Son, Shuraku
AU - Narita, Hisashi
AU - Yamamoto, Maeri
AU - Tha, Khin Khin
AU - Katsuki, Asuka
AU - Ohi, Kazutaka
AU - Yamashita, Fumio
AU - Koike, Shinsuke
AU - Takahashi, Tsutomu
AU - Nemoto, Kiyotaka
AU - Fukunaga, Masaki
AU - Onitsuka, Toshiaki
AU - Watanabe, Yoshiyuki
AU - Yamasue, Hidenori
AU - Suzuki, Michio
AU - Kasai, Kiyoto
AU - Kusumi, Ichiro
AU - Hashimoto, Ryota
N1 - Funding Information:
This work was supported by the Japan Agency for Medical Research and Development ( 17dm0207004h0004 ) (the Brain Mapping by Integrated Neurotechnologies for Disease Studies) and the Ministry of Education, Culture, Sports, Science and Technology (Advanced Bioimaging Support 16H06280 , KAKENHI 16H05375 ). The funding sources had no role in the study design; data collection, analysis, and interpretation; writing of the report; or the decision to submit the paper.
Publisher Copyright:
© 2017 The Authors
PY - 2018
Y1 - 2018
N2 - Background The effect of duration of illness and antipsychotic medication on the volumes of subcortical structures in schizophrenia is inconsistent among previous reports. We implemented a large sample analysis utilizing clinical data from 11 institutions in a previous meta-analysis. Methods Imaging and clinical data of 778 schizophrenia subjects were taken from a prospective meta-analysis conducted by the COCORO consortium in Japan. The effect of duration of illness and daily dose and type of antipsychotics were assessed using the linear mixed effect model where the volumes of subcortical structures computed by FreeSurfer were used as a dependent variable and age, sex, duration of illness, daily dose of antipsychotics and intracranial volume were used as independent variables, and the type of protocol was incorporated as a random effect for intercept. The statistical significance of fixed-effect of dependent variable was assessed. Results Daily dose of antipsychotics was positively associated with left globus pallidus volume and negatively associated with right hippocampus. It was also positively associated with laterality index of globus pallidus. Duration of illness was positively associated with bilateral globus pallidus volumes. Type of antipsychotics did not have any effect on the subcortical volumes. Discussion A large sample size, uniform data collection methodology and robust statistical analysis are strengths of the current study. This result suggests that we need special attention to discuss about relationship between subcortical regional brain volumes and pathophysiology of schizophrenia because regional brain volumes may be affected by antipsychotic medication.
AB - Background The effect of duration of illness and antipsychotic medication on the volumes of subcortical structures in schizophrenia is inconsistent among previous reports. We implemented a large sample analysis utilizing clinical data from 11 institutions in a previous meta-analysis. Methods Imaging and clinical data of 778 schizophrenia subjects were taken from a prospective meta-analysis conducted by the COCORO consortium in Japan. The effect of duration of illness and daily dose and type of antipsychotics were assessed using the linear mixed effect model where the volumes of subcortical structures computed by FreeSurfer were used as a dependent variable and age, sex, duration of illness, daily dose of antipsychotics and intracranial volume were used as independent variables, and the type of protocol was incorporated as a random effect for intercept. The statistical significance of fixed-effect of dependent variable was assessed. Results Daily dose of antipsychotics was positively associated with left globus pallidus volume and negatively associated with right hippocampus. It was also positively associated with laterality index of globus pallidus. Duration of illness was positively associated with bilateral globus pallidus volumes. Type of antipsychotics did not have any effect on the subcortical volumes. Discussion A large sample size, uniform data collection methodology and robust statistical analysis are strengths of the current study. This result suggests that we need special attention to discuss about relationship between subcortical regional brain volumes and pathophysiology of schizophrenia because regional brain volumes may be affected by antipsychotic medication.
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U2 - 10.1016/j.nicl.2017.11.004
DO - 10.1016/j.nicl.2017.11.004
M3 - Article
C2 - 29201642
AN - SCOPUS:85034748071
VL - 17
SP - 563
EP - 569
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
SN - 2213-1582
ER -