The effect of interleukin-1β on the efferent activity of the vagus nerve to the thymus

Akira Niijima, Tetsuro Hori, Toshihiko Katafuchi, Tomoyasu Ichijo

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The effects of intravenous (i.v.) administration of recombinant human interleukin-1β (rhIL-1β) and human interleukin-1β-fraction (hfrIL-1β) on the activity of vagal efferent fibers innervating the thymus were observed in urethane-anesthetized rats. An i.v. injection of 10 ng rhIL-1β or hfrIL-1β caused a similar degree of increase in the efferent activity, which lasted longer than 2 h. The least effective dose was 1 ng and dose-dependent responses were observed after i.v. injection of rhIL-1β at doses of 1 ng, 10 ng and 100 ng. The IL-1β-induced activation of efferent activity of the vagal branch to the thymus implicates their involvement in the neural modulation of the thymic function.

Original languageEnglish
Pages (from-to)137-144
Number of pages8
JournalJournal of the Autonomic Nervous System
Volume54
Issue number2
DOIs
Publication statusPublished - Aug 4 1995

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Vagus Nerve
Interleukin-1
Thymus Gland
Intravenous Injections
Urethane
Intravenous Administration

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology
  • Clinical Neurology

Cite this

The effect of interleukin-1β on the efferent activity of the vagus nerve to the thymus. / Niijima, Akira; Hori, Tetsuro; Katafuchi, Toshihiko; Ichijo, Tomoyasu.

In: Journal of the Autonomic Nervous System, Vol. 54, No. 2, 04.08.1995, p. 137-144.

Research output: Contribution to journalArticle

Niijima, Akira ; Hori, Tetsuro ; Katafuchi, Toshihiko ; Ichijo, Tomoyasu. / The effect of interleukin-1β on the efferent activity of the vagus nerve to the thymus. In: Journal of the Autonomic Nervous System. 1995 ; Vol. 54, No. 2. pp. 137-144.
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