The effect of IPD in atopic dermatitis

Shuji Fukagawa, Masutaka Furue

Research output: Contribution to journalArticle

Abstract

Besides having an inhibitory effect of chemical mediator release from mast cells, IPD has an inhibitory effect of Th2 cytokines (IgE production by IL-4 inhibition and eosinophil proliferation by IL-5 inhibition). We administered IPD to patients with atopic dermatitis and evaluated the blood levels of IgE and eosinophil counts. IPD significantly improved the severity of the skin, but did not influence the IgE production and eosinophil number. However, IPD potentiy decreased the levels of IgE in 2 patients with marked hyperimmunoglobulinemia E. These results suggest that IPD is markedly useful in a certain group of patients with atopic dermatitis.

Original languageEnglish
Pages (from-to)38-44
Number of pages7
JournalSkin Research
Volume6
Issue numberSUPPL. 8
Publication statusPublished - Mar 1 2007

Fingerprint

Atopic Dermatitis
Immunoglobulin E
Eosinophils
Hypergammaglobulinemia
Interleukin-5
Mast Cells
Interleukin-4
Cytokines
Skin

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases

Cite this

Fukagawa, S., & Furue, M. (2007). The effect of IPD in atopic dermatitis. Skin Research, 6(SUPPL. 8), 38-44.

The effect of IPD in atopic dermatitis. / Fukagawa, Shuji; Furue, Masutaka.

In: Skin Research, Vol. 6, No. SUPPL. 8, 01.03.2007, p. 38-44.

Research output: Contribution to journalArticle

Fukagawa, S & Furue, M 2007, 'The effect of IPD in atopic dermatitis', Skin Research, vol. 6, no. SUPPL. 8, pp. 38-44.
Fukagawa S, Furue M. The effect of IPD in atopic dermatitis. Skin Research. 2007 Mar 1;6(SUPPL. 8):38-44.
Fukagawa, Shuji ; Furue, Masutaka. / The effect of IPD in atopic dermatitis. In: Skin Research. 2007 ; Vol. 6, No. SUPPL. 8. pp. 38-44.
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