Abstract
Besides having an inhibitory effect of chemical mediator release from mast cells, IPD has an inhibitory effect of Th2 cytokines (IgE production by IL-4 inhibition and eosinophil proliferation by IL-5 inhibition). We administered IPD to patients with atopic dermatitis and evaluated the blood levels of IgE and eosinophil counts. IPD significantly improved the severity of the skin, but did not influence the IgE production and eosinophil number. However, IPD potentiy decreased the levels of IgE in 2 patients with marked hyperimmunoglobulinemia E. These results suggest that IPD is markedly useful in a certain group of patients with atopic dermatitis.
| Original language | English |
|---|---|
| Pages (from-to) | 38-44 |
| Number of pages | 7 |
| Journal | Skin Research |
| Volume | 6 |
| Issue number | SUPPL. 8 |
| Publication status | Published - Mar 1 2007 |
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All Science Journal Classification (ASJC) codes
- Dermatology
- Infectious Diseases
Cite this
The effect of IPD in atopic dermatitis. / Fukagawa, Shuji; Furue, Masutaka.
In: Skin Research, Vol. 6, No. SUPPL. 8, 01.03.2007, p. 38-44.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of IPD in atopic dermatitis
AU - Fukagawa, Shuji
AU - Furue, Masutaka
PY - 2007/3/1
Y1 - 2007/3/1
N2 - Besides having an inhibitory effect of chemical mediator release from mast cells, IPD has an inhibitory effect of Th2 cytokines (IgE production by IL-4 inhibition and eosinophil proliferation by IL-5 inhibition). We administered IPD to patients with atopic dermatitis and evaluated the blood levels of IgE and eosinophil counts. IPD significantly improved the severity of the skin, but did not influence the IgE production and eosinophil number. However, IPD potentiy decreased the levels of IgE in 2 patients with marked hyperimmunoglobulinemia E. These results suggest that IPD is markedly useful in a certain group of patients with atopic dermatitis.
AB - Besides having an inhibitory effect of chemical mediator release from mast cells, IPD has an inhibitory effect of Th2 cytokines (IgE production by IL-4 inhibition and eosinophil proliferation by IL-5 inhibition). We administered IPD to patients with atopic dermatitis and evaluated the blood levels of IgE and eosinophil counts. IPD significantly improved the severity of the skin, but did not influence the IgE production and eosinophil number. However, IPD potentiy decreased the levels of IgE in 2 patients with marked hyperimmunoglobulinemia E. These results suggest that IPD is markedly useful in a certain group of patients with atopic dermatitis.
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UR - http://www.scopus.com/inward/citedby.url?scp=34249062696&partnerID=8YFLogxK
M3 - Article
VL - 6
SP - 38
EP - 44
JO - Skin Research
JF - Skin Research
SN - 0018-1390
IS - SUPPL. 8
ER -