The effect of prostacyclin on the gastric mucosa in portal-hypertensive rats

Fumiaki Kishihara, Makoto Hashizume, Masayuki Ohta, Hirofumi Kawanaka, Morimasa Tomikawa, Hidefumi Higashi, Kazuo Tanoue, Keizo Sugimachi

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Abstract

Background/Aims: This study investigates the effect of prostacyclin, which is thought to be involved in the hemodynamic circulation, on the gastric mucosa of rats with portal hypertension. Methodology: Various gastric functions were evaluated in portal vein ligated rats after the intraperitoneal administration of either a placebo or prostacyclin for 7 days. Results: The gastric mucosal damage induced by the instillation of 90% ethanol was significantly greater in the prostacyclin-treated group than in placebo-treated group. The portal pressure was similar in both groups. There was no significant difference between the two groups in plasma concentration of 6-keto-PGF1a (a stable metabolite of prostacyclin), whereas the mucosal content of 6-keto-PGF1a was significantly higher in the prostacyclin-treated group than in the placebo-treated group. Prostacyclin pre-treatment significantly increased the gastric mucosal blood flow, estimated by laser-Doppler flowmetry, and the hemoglobin content of the gastric mucosa, measured by reflectance spectrophotometry, whereas the oxygen content remained unchanged. Conclusions: We speculate that the increased gastric mucosal perfusion induced by a high content of prostacyclin in the portal hypertensive gastric mucosa may play a role in the pathogenesis of ethanol-induced gastric mucosal damage.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalHepato-gastroenterology
Volume49
Issue number43
Publication statusPublished - Apr 18 2002

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All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Kishihara, F., Hashizume, M., Ohta, M., Kawanaka, H., Tomikawa, M., Higashi, H., ... Sugimachi, K. (2002). The effect of prostacyclin on the gastric mucosa in portal-hypertensive rats. Hepato-gastroenterology, 49(43), 279-284.