The effects of ototoxic drugs on mechano-electric transduction channels in chick cochlear hair cells

T. Kimitsuki, T. Nakagawa, K. Hisashi, S. Komune, T. Uemura

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effects of ototoxic drugs on mechano-electrical transduction (MET) currents were investigated in dissociated cochlear hair cells of the chick, using a wholecell patch-electrode voltage-clamp technique. Dihydrostreptomycin (DHSM) and cisplatin (cis-dichlorodiammine platinum II, CDDP) blocked the MET channel in a dose- and voltage-dependent manner. In contrast, acetyl salicylate did not suppress the MET current. At -50 mV, DHSM and CDDP blocked the MET channel with a Hill coefficient of 0.93 and 2.1, respectively. These findings suggest that a single DHSM molecule or more than one CDDP molecule binds to a single MET channel.

Original languageEnglish
Pages (from-to)S53-S56
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume251
Issue number1 Supplement
DOIs
Publication statusPublished - Aug 1 1994

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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