The effects of ototoxic drugs on mechano-electric transduction channels in chick cochlear hair cells

T. Kimitsuki, Takashi Nakagawa, K. Hisashi, S. Komune, T. Uemura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of ototoxic drugs on mechano-electrical transduction (MET) currents were investigated in dissociated cochlear hair cells of the chick, using a wholecell patch-electrode voltage-clamp technique. Dihydrostreptomycin (DHSM) and cisplatin (cis-dichlorodiammine platinum II, CDDP) blocked the MET channel in a dose- and voltage-dependent manner. In contrast, acetyl salicylate did not suppress the MET current. At -50 mV, DHSM and CDDP blocked the MET channel with a Hill coefficient of 0.93 and 2.1, respectively. These findings suggest that a single DHSM molecule or more than one CDDP molecule binds to a single MET channel.

Original languageEnglish
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume251
Issue number1 Supplement
DOIs
Publication statusPublished - Aug 1 1994

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Auditory Hair Cells
Dihydrostreptomycin Sulfate
Cisplatin
Pharmaceutical Preparations
Salicylates
Patch-Clamp Techniques
Electrodes

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

The effects of ototoxic drugs on mechano-electric transduction channels in chick cochlear hair cells. / Kimitsuki, T.; Nakagawa, Takashi; Hisashi, K.; Komune, S.; Uemura, T.

In: European Archives of Oto-Rhino-Laryngology, Vol. 251, No. 1 Supplement, 01.08.1994.

Research output: Contribution to journalArticle

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