TY - JOUR
T1 - The effects of various metallic surfaces on cellular and bacterial adhesion
AU - Shimabukuro, Masaya
AU - Ito, Haruka
AU - Tsutsumi, Yusuke
AU - Nozaki, Kosuke
AU - Chen, Peng
AU - Yamada, Risa
AU - Ashida, Maki
AU - Nagai, Akiko
AU - Hanawa, Takao
N1 - Funding Information:
Acknowledgments: This study was supported by the Research Center for Biomedical Engineering, Tokyo Medical and Dental University, Project “Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development” and project “Cooperative project amount medicine, dentistry, and engineering for medical innovation-Construction of creative scientific research of the viable material via integration of biology and engineering” by the Ministry of Education, Culture, Sports, Science and Engineering, Japan.
Publisher Copyright:
© 2019, MDPI AG. All rights reserved.
PY - 2019/11
Y1 - 2019/11
N2 - The effects of Ti, Nb, Ta, Zr, and Ag on cellular and bacterial adhesion were investigated in this study. Moreover, the relationships between surface compositions, metal ion release behaviors, and biological responses were examined. As a result, MC3T3-E1 cells and S. aureus were able to better attach to Ti and Zr rather than the Nb and Ta specimens. For the Ag specimen, the amount of Ag ions released into Hanks’ solution was the largest among all the specimens. Cellular and bacterial adhesion onto the Ag specimen was inhibited compared with the other specimens, because of Ag ion release. Alternatively, Nb and Ta specimens exhibited specific biological responses. Cellular adhesion on Nb and Ta specimens was similar to that on Ti, while bacterial adhesion on Nb and Ta specimens was inhibited compared with that on Ti. This study proved that Nb and Ta inhibited bacterial adhesion and exhibited no harmful effects on cellular adhesion. In addition, these results indicate that the passive layer on Nb and Ta plays a key role in the inhibition of bacterial adhesion.
AB - The effects of Ti, Nb, Ta, Zr, and Ag on cellular and bacterial adhesion were investigated in this study. Moreover, the relationships between surface compositions, metal ion release behaviors, and biological responses were examined. As a result, MC3T3-E1 cells and S. aureus were able to better attach to Ti and Zr rather than the Nb and Ta specimens. For the Ag specimen, the amount of Ag ions released into Hanks’ solution was the largest among all the specimens. Cellular and bacterial adhesion onto the Ag specimen was inhibited compared with the other specimens, because of Ag ion release. Alternatively, Nb and Ta specimens exhibited specific biological responses. Cellular adhesion on Nb and Ta specimens was similar to that on Ti, while bacterial adhesion on Nb and Ta specimens was inhibited compared with that on Ti. This study proved that Nb and Ta inhibited bacterial adhesion and exhibited no harmful effects on cellular adhesion. In addition, these results indicate that the passive layer on Nb and Ta plays a key role in the inhibition of bacterial adhesion.
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U2 - 10.3390/met9111145
DO - 10.3390/met9111145
M3 - Article
AN - SCOPUS:85078134247
VL - 9
JO - Metals
JF - Metals
SN - 2075-4701
IS - 11
M1 - 1145
ER -