The efficient entry into the tricyclic core of halichlorine

Mitsuru Shindo, Yu Ichi Fukuda, Kozo Shishido

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

An efficient and diastereoselective synthesis of the tricyclic core structure 3 found in the marine alkaloid halichlorine 1 has been accomplished starting from Grigg's tricyclic isoxazolidine 5, which was prepared by the tandem intramolecular Michael addition-[3+2] cycloaddition of the corresponding oxime of 4. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)929-932
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number6
DOIs
Publication statusPublished - Feb 5 2000
Externally publishedYes

Fingerprint

Oximes
Cycloaddition
Cycloaddition Reaction
Alkaloids
halichlorine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

The efficient entry into the tricyclic core of halichlorine. / Shindo, Mitsuru; Fukuda, Yu Ichi; Shishido, Kozo.

In: Tetrahedron Letters, Vol. 41, No. 6, 05.02.2000, p. 929-932.

Research output: Contribution to journalArticle

Shindo, Mitsuru ; Fukuda, Yu Ichi ; Shishido, Kozo. / The efficient entry into the tricyclic core of halichlorine. In: Tetrahedron Letters. 2000 ; Vol. 41, No. 6. pp. 929-932.
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