The end group modification of phospholipid polymer brush grafted on ferric oxide nanoparticles for diagnostics

Ryosuke Matsuno, Kazuhiko Ishihara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The end group of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer brush on ferric oxide (Fe3O4) nanoparticles was converted from bromine (Br) to amine (NH2) by "staudinger reduction". At first, poly(MPC) was grafted by atom transfer radical polymerization (ATRP) from surface initiator fixed on Fe3O4 nanoparticles. Br element located in MPC polymer brush was converted to azide (N3). Consequently, N3 was converted to NH2 using triphenyl phosphine (PPh3) and H2O. Characterization at each step was confirmed by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FT-IR) measurements. As an example aiming for diagnostic material, fluorescein isothiocyanate (FITC) was able to immobilize via reaction between NH2 group located on the end of poly(MPC) chain and isothiocyanate. The surface structure own ability of capture biomolecular throw condensation between amine in polymer brush and carboxyl group in biomolecular.

Original languageEnglish
Title of host publicationDesigner Biointerfaces
PublisherMaterials Research Society
Pages1-5
Number of pages5
ISBN (Print)9781605608471
DOIs
Publication statusPublished - 2008
Externally publishedYes

Publication series

NameMaterials Research Society Symposium Proceedings
Volume1093
ISSN (Print)0272-9172

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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