TY - GEN
T1 - The end group modification of phospholipid polymer brush grafted on ferric oxide nanoparticles for diagnostics
AU - Matsuno, Ryosuke
AU - Ishihara, Kazuhiko
PY - 2008
Y1 - 2008
N2 - The end group of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer brush on ferric oxide (Fe3O4) nanoparticles was converted from bromine (Br) to amine (NH2) by "staudinger reduction". At first, poly(MPC) was grafted by atom transfer radical polymerization (ATRP) from surface initiator fixed on Fe3O4 nanoparticles. Br element located in MPC polymer brush was converted to azide (N3). Consequently, N3 was converted to NH2 using triphenyl phosphine (PPh3) and H2O. Characterization at each step was confirmed by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FT-IR) measurements. As an example aiming for diagnostic material, fluorescein isothiocyanate (FITC) was able to immobilize via reaction between NH2 group located on the end of poly(MPC) chain and isothiocyanate. The surface structure own ability of capture biomolecular throw condensation between amine in polymer brush and carboxyl group in biomolecular.
AB - The end group of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer brush on ferric oxide (Fe3O4) nanoparticles was converted from bromine (Br) to amine (NH2) by "staudinger reduction". At first, poly(MPC) was grafted by atom transfer radical polymerization (ATRP) from surface initiator fixed on Fe3O4 nanoparticles. Br element located in MPC polymer brush was converted to azide (N3). Consequently, N3 was converted to NH2 using triphenyl phosphine (PPh3) and H2O. Characterization at each step was confirmed by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FT-IR) measurements. As an example aiming for diagnostic material, fluorescein isothiocyanate (FITC) was able to immobilize via reaction between NH2 group located on the end of poly(MPC) chain and isothiocyanate. The surface structure own ability of capture biomolecular throw condensation between amine in polymer brush and carboxyl group in biomolecular.
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U2 - 10.1557/proc-1093-cc04-11
DO - 10.1557/proc-1093-cc04-11
M3 - Conference contribution
AN - SCOPUS:77957950497
SN - 9781605608471
T3 - Materials Research Society Symposium Proceedings
SP - 1
EP - 5
BT - Designer Biointerfaces
PB - Materials Research Society
ER -