<i>Sinanodonta woodiana</i> is widely distributed throughout Chinese freshwaters and is an important economic pearl mollusk. In order to evaluate the application feasibility of <i>S. woodiana</i> as a <i>Microcystis</i>-blooming removal tool, a series of microcosm experiments were performed. First the 6-day feeding responses experiment was carried out with naturally blooming pond water and the bivalves in laboratory, which was lasted for 6 days. In this experiment, phytoplankton abundances and community structure were analyzed on 0-day and 6-day for both control and treatment microcosms; also, filtration rate, absorption efficiency, oxygen consumption rate and ammonia excretion rate of <i>S. woodiana</i> were measured on 0-day and 6-day and finally the scope for growth (SFG) value as a measure of metabolic energy balance for <i>S. woodiana</i> was calculated and compared. The results showed that <i>Microcystis</i> spp. of colony and unicell were reduced obviously on the 6-day; meanwhile, after six day's exposure to <i>Microcystis</i>-blooming pond water, the SFG value for <i>S. woodiana</i> increased. Furthermore, in the extended long-term grazing experiment, bivalves were fed with highly concentrated toxic <i>Microcystis</i>-blooming water and non-toxic <i>Chlorella</i> at the constant concentration (Chl.a=424.5 mg/m<sup>3</sup>) in two respective tanks for 12 days. No bivalve mortality was registered on both <i>Chlorella</i> group and blooming water group. In addition, SFGs were significantly higher for the blooming water group, compared with them for <i>Chlorella</i> group on 3-day, 6-day and 12-day. These results indicated that toxic <i>Microcystis</i> spp. in natural eutrophic water can be removed greatly by <i>S. woodiana</i>; moreover, the bivalves themselves have strong adaptation ability when they were exposed to toxic natural eutrophic water. Therefore, it can be inferred that there is high application feasibility of <i>S. woodiana</i> as a <i>Microcystis</i>-blooming controller in practice.