Abstract
Purpose: For 30 years, we have consecutively performed rectal mucosal punch biopsy to diagnose Hirschsprung’s disease. The aim of this study was to evaluate the safety of our technique. Methods: Patients with suspected Hirschsprung’s disease who underwent punch biopsy, including our original “K-PUNCH” method using an S-moid forceps and non-specific blood-collecting tube at our department and branch hospital between April 1986 and March 2016 were included in the present study. Our punch biopsy technique is characterized by excellent visibility and a direct grasping sensation. The backgrounds and complications of the patients were retrospectively investigated. Results: During this period, 954 patients (median age 4 months; range 1 day–73 years) underwent punch biopsy. Although there were no cases of severe complications (i.e., rectal perforation, infection or full-thickness biopsy), one (0.1%) of the 954 cases in the early period showed liver dysfunction and required transfusion due to bleeding. In addition, inappropriate specimens were obtained in 37 patients (3.9%). Conclusion: Punch biopsy including the “K-PUNCH” method is considered safe and feasible and is associated with a low rate of complications and inappropriate specimen harvesting among patients of all ages. Comorbidities, including the potential for hemorrhage, should always be considered.
| Original language | English |
|---|---|
| Pages (from-to) | 173-179 |
| Number of pages | 7 |
| Journal | Pediatric surgery international |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2017 |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Surgery
Cite this
The evaluation of rectal mucosal punch biopsy in the diagnosis of Hirschsprung’s disease : a 30-year experience of 954 patients. / Yoshimaru, Koichiro; Kinoshita, Yoshiaki; Yanagi, Yusuke; Obata, Satoshi; Jimbo, Takahiro; Iwanaka, Tsuyoshi; Takahashi, Yoshiaki; Esumi, Genshiro; Miyata, Junko A.; Matsuura, Toshiharu; Izaki, Tomoko; Taguchi, Tomoaki.
In: Pediatric surgery international, Vol. 33, No. 2, 01.02.2017, p. 173-179.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The evaluation of rectal mucosal punch biopsy in the diagnosis of Hirschsprung’s disease
T2 - a 30-year experience of 954 patients
AU - Yoshimaru, Koichiro
AU - Kinoshita, Yoshiaki
AU - Yanagi, Yusuke
AU - Obata, Satoshi
AU - Jimbo, Takahiro
AU - Iwanaka, Tsuyoshi
AU - Takahashi, Yoshiaki
AU - Esumi, Genshiro
AU - Miyata, Junko A.
AU - Matsuura, Toshiharu
AU - Izaki, Tomoko
AU - Taguchi, Tomoaki
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Purpose: For 30 years, we have consecutively performed rectal mucosal punch biopsy to diagnose Hirschsprung’s disease. The aim of this study was to evaluate the safety of our technique. Methods: Patients with suspected Hirschsprung’s disease who underwent punch biopsy, including our original “K-PUNCH” method using an S-moid forceps and non-specific blood-collecting tube at our department and branch hospital between April 1986 and March 2016 were included in the present study. Our punch biopsy technique is characterized by excellent visibility and a direct grasping sensation. The backgrounds and complications of the patients were retrospectively investigated. Results: During this period, 954 patients (median age 4 months; range 1 day–73 years) underwent punch biopsy. Although there were no cases of severe complications (i.e., rectal perforation, infection or full-thickness biopsy), one (0.1%) of the 954 cases in the early period showed liver dysfunction and required transfusion due to bleeding. In addition, inappropriate specimens were obtained in 37 patients (3.9%). Conclusion: Punch biopsy including the “K-PUNCH” method is considered safe and feasible and is associated with a low rate of complications and inappropriate specimen harvesting among patients of all ages. Comorbidities, including the potential for hemorrhage, should always be considered.
AB - Purpose: For 30 years, we have consecutively performed rectal mucosal punch biopsy to diagnose Hirschsprung’s disease. The aim of this study was to evaluate the safety of our technique. Methods: Patients with suspected Hirschsprung’s disease who underwent punch biopsy, including our original “K-PUNCH” method using an S-moid forceps and non-specific blood-collecting tube at our department and branch hospital between April 1986 and March 2016 were included in the present study. Our punch biopsy technique is characterized by excellent visibility and a direct grasping sensation. The backgrounds and complications of the patients were retrospectively investigated. Results: During this period, 954 patients (median age 4 months; range 1 day–73 years) underwent punch biopsy. Although there were no cases of severe complications (i.e., rectal perforation, infection or full-thickness biopsy), one (0.1%) of the 954 cases in the early period showed liver dysfunction and required transfusion due to bleeding. In addition, inappropriate specimens were obtained in 37 patients (3.9%). Conclusion: Punch biopsy including the “K-PUNCH” method is considered safe and feasible and is associated with a low rate of complications and inappropriate specimen harvesting among patients of all ages. Comorbidities, including the potential for hemorrhage, should always be considered.
UR - http://www.scopus.com/inward/record.url?scp=84994749755&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994749755&partnerID=8YFLogxK
U2 - 10.1007/s00383-016-4010-2
DO - 10.1007/s00383-016-4010-2
M3 - Article
C2 - 27832330
AN - SCOPUS:84994749755
VL - 33
SP - 173
EP - 179
JO - Pediatric Surgery International
JF - Pediatric Surgery International
SN - 0179-0358
IS - 2
ER -