TY - JOUR
T1 - The evaluation of rectal mucosal punch biopsy in the diagnosis of Hirschsprung’s disease
T2 - a 30-year experience of 954 patients
AU - Yoshimaru, Koichiro
AU - Kinoshita, Yoshiaki
AU - Yanagi, Yusuke
AU - Obata, Satoshi
AU - Jimbo, Takahiro
AU - Iwanaka, Tsuyoshi
AU - Takahashi, Yoshiaki
AU - Esumi, Genshiro
AU - Miyata, Junko A.
AU - Matsuura, Toshiharu
AU - Izaki, Tomoko
AU - Taguchi, Tomoaki
N1 - Funding Information:
The present study was supported in part by Grants from The Ministry of Health, Labour Sciences Research Grants for Research on Intractable Diseases (H26-045). The authors thank Takaharu Yamada (Department of Surgery, Ehime University, Toon, Japan), Ryuichiro Hirose (Department of Pediatric Surgery, Fukuoka University, Fukuoka, Japan) and Isamu Saeki (Department of Pediatric Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan) for their helpful advice, and Brian Quinn (Editor-in-Chief, Japan Medical Communication, Inc., Fukuoka, Japan) for his assistance in the reading and editing of the English language of this manuscript.
Publisher Copyright:
© 2016, Springer-Verlag Berlin Heidelberg.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Purpose: For 30 years, we have consecutively performed rectal mucosal punch biopsy to diagnose Hirschsprung’s disease. The aim of this study was to evaluate the safety of our technique. Methods: Patients with suspected Hirschsprung’s disease who underwent punch biopsy, including our original “K-PUNCH” method using an S-moid forceps and non-specific blood-collecting tube at our department and branch hospital between April 1986 and March 2016 were included in the present study. Our punch biopsy technique is characterized by excellent visibility and a direct grasping sensation. The backgrounds and complications of the patients were retrospectively investigated. Results: During this period, 954 patients (median age 4 months; range 1 day–73 years) underwent punch biopsy. Although there were no cases of severe complications (i.e., rectal perforation, infection or full-thickness biopsy), one (0.1%) of the 954 cases in the early period showed liver dysfunction and required transfusion due to bleeding. In addition, inappropriate specimens were obtained in 37 patients (3.9%). Conclusion: Punch biopsy including the “K-PUNCH” method is considered safe and feasible and is associated with a low rate of complications and inappropriate specimen harvesting among patients of all ages. Comorbidities, including the potential for hemorrhage, should always be considered.
AB - Purpose: For 30 years, we have consecutively performed rectal mucosal punch biopsy to diagnose Hirschsprung’s disease. The aim of this study was to evaluate the safety of our technique. Methods: Patients with suspected Hirschsprung’s disease who underwent punch biopsy, including our original “K-PUNCH” method using an S-moid forceps and non-specific blood-collecting tube at our department and branch hospital between April 1986 and March 2016 were included in the present study. Our punch biopsy technique is characterized by excellent visibility and a direct grasping sensation. The backgrounds and complications of the patients were retrospectively investigated. Results: During this period, 954 patients (median age 4 months; range 1 day–73 years) underwent punch biopsy. Although there were no cases of severe complications (i.e., rectal perforation, infection or full-thickness biopsy), one (0.1%) of the 954 cases in the early period showed liver dysfunction and required transfusion due to bleeding. In addition, inappropriate specimens were obtained in 37 patients (3.9%). Conclusion: Punch biopsy including the “K-PUNCH” method is considered safe and feasible and is associated with a low rate of complications and inappropriate specimen harvesting among patients of all ages. Comorbidities, including the potential for hemorrhage, should always be considered.
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U2 - 10.1007/s00383-016-4010-2
DO - 10.1007/s00383-016-4010-2
M3 - Article
C2 - 27832330
AN - SCOPUS:84994749755
VL - 33
SP - 173
EP - 179
JO - Pediatric Surgery International
JF - Pediatric Surgery International
SN - 0179-0358
IS - 2
ER -