The evaluation of rectal mucosal punch biopsy in the diagnosis of Hirschsprung’s disease: a 30-year experience of 954 patients

Koichiro Yoshimaru, Yoshiaki Kinoshita, Yusuke Yanagi, Satoshi Obata, Takahiro Jimbo, Tsuyoshi Iwanaka, Yoshiaki Takahashi, Genshiro Esumi, Junko Miyata, Toshiharu Matsuura, Tomoko Izaki, Tomoaki Taguchi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: For 30 years, we have consecutively performed rectal mucosal punch biopsy to diagnose Hirschsprung’s disease. The aim of this study was to evaluate the safety of our technique. Methods: Patients with suspected Hirschsprung’s disease who underwent punch biopsy, including our original “K-PUNCH” method using an S-moid forceps and non-specific blood-collecting tube at our department and branch hospital between April 1986 and March 2016 were included in the present study. Our punch biopsy technique is characterized by excellent visibility and a direct grasping sensation. The backgrounds and complications of the patients were retrospectively investigated. Results: During this period, 954 patients (median age 4 months; range 1 day–73 years) underwent punch biopsy. Although there were no cases of severe complications (i.e., rectal perforation, infection or full-thickness biopsy), one (0.1%) of the 954 cases in the early period showed liver dysfunction and required transfusion due to bleeding. In addition, inappropriate specimens were obtained in 37 patients (3.9%). Conclusion: Punch biopsy including the “K-PUNCH” method is considered safe and feasible and is associated with a low rate of complications and inappropriate specimen harvesting among patients of all ages. Comorbidities, including the potential for hemorrhage, should always be considered.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalPediatric surgery international
Volume33
Issue number2
DOIs
Publication statusPublished - Feb 1 2017

Fingerprint

Hirschsprung Disease
Biopsy
Satellite Hospitals
Hemorrhage
Surgical Instruments
Comorbidity
Liver Diseases
Safety
Infection

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

The evaluation of rectal mucosal punch biopsy in the diagnosis of Hirschsprung’s disease : a 30-year experience of 954 patients. / Yoshimaru, Koichiro; Kinoshita, Yoshiaki; Yanagi, Yusuke; Obata, Satoshi; Jimbo, Takahiro; Iwanaka, Tsuyoshi; Takahashi, Yoshiaki; Esumi, Genshiro; Miyata, Junko; Matsuura, Toshiharu; Izaki, Tomoko; Taguchi, Tomoaki.

In: Pediatric surgery international, Vol. 33, No. 2, 01.02.2017, p. 173-179.

Research output: Contribution to journalArticle

@article{c7e9b7eecf804a2aa4469ed139d14c09,
title = "The evaluation of rectal mucosal punch biopsy in the diagnosis of Hirschsprung’s disease: a 30-year experience of 954 patients",
abstract = "Purpose: For 30 years, we have consecutively performed rectal mucosal punch biopsy to diagnose Hirschsprung’s disease. The aim of this study was to evaluate the safety of our technique. Methods: Patients with suspected Hirschsprung’s disease who underwent punch biopsy, including our original “K-PUNCH” method using an S-moid forceps and non-specific blood-collecting tube at our department and branch hospital between April 1986 and March 2016 were included in the present study. Our punch biopsy technique is characterized by excellent visibility and a direct grasping sensation. The backgrounds and complications of the patients were retrospectively investigated. Results: During this period, 954 patients (median age 4 months; range 1 day–73 years) underwent punch biopsy. Although there were no cases of severe complications (i.e., rectal perforation, infection or full-thickness biopsy), one (0.1{\%}) of the 954 cases in the early period showed liver dysfunction and required transfusion due to bleeding. In addition, inappropriate specimens were obtained in 37 patients (3.9{\%}). Conclusion: Punch biopsy including the “K-PUNCH” method is considered safe and feasible and is associated with a low rate of complications and inappropriate specimen harvesting among patients of all ages. Comorbidities, including the potential for hemorrhage, should always be considered.",
author = "Koichiro Yoshimaru and Yoshiaki Kinoshita and Yusuke Yanagi and Satoshi Obata and Takahiro Jimbo and Tsuyoshi Iwanaka and Yoshiaki Takahashi and Genshiro Esumi and Junko Miyata and Toshiharu Matsuura and Tomoko Izaki and Tomoaki Taguchi",
year = "2017",
month = "2",
day = "1",
doi = "10.1007/s00383-016-4010-2",
language = "English",
volume = "33",
pages = "173--179",
journal = "Pediatric Surgery International",
issn = "0179-0358",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - The evaluation of rectal mucosal punch biopsy in the diagnosis of Hirschsprung’s disease

T2 - a 30-year experience of 954 patients

AU - Yoshimaru, Koichiro

AU - Kinoshita, Yoshiaki

AU - Yanagi, Yusuke

AU - Obata, Satoshi

AU - Jimbo, Takahiro

AU - Iwanaka, Tsuyoshi

AU - Takahashi, Yoshiaki

AU - Esumi, Genshiro

AU - Miyata, Junko

AU - Matsuura, Toshiharu

AU - Izaki, Tomoko

AU - Taguchi, Tomoaki

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Purpose: For 30 years, we have consecutively performed rectal mucosal punch biopsy to diagnose Hirschsprung’s disease. The aim of this study was to evaluate the safety of our technique. Methods: Patients with suspected Hirschsprung’s disease who underwent punch biopsy, including our original “K-PUNCH” method using an S-moid forceps and non-specific blood-collecting tube at our department and branch hospital between April 1986 and March 2016 were included in the present study. Our punch biopsy technique is characterized by excellent visibility and a direct grasping sensation. The backgrounds and complications of the patients were retrospectively investigated. Results: During this period, 954 patients (median age 4 months; range 1 day–73 years) underwent punch biopsy. Although there were no cases of severe complications (i.e., rectal perforation, infection or full-thickness biopsy), one (0.1%) of the 954 cases in the early period showed liver dysfunction and required transfusion due to bleeding. In addition, inappropriate specimens were obtained in 37 patients (3.9%). Conclusion: Punch biopsy including the “K-PUNCH” method is considered safe and feasible and is associated with a low rate of complications and inappropriate specimen harvesting among patients of all ages. Comorbidities, including the potential for hemorrhage, should always be considered.

AB - Purpose: For 30 years, we have consecutively performed rectal mucosal punch biopsy to diagnose Hirschsprung’s disease. The aim of this study was to evaluate the safety of our technique. Methods: Patients with suspected Hirschsprung’s disease who underwent punch biopsy, including our original “K-PUNCH” method using an S-moid forceps and non-specific blood-collecting tube at our department and branch hospital between April 1986 and March 2016 were included in the present study. Our punch biopsy technique is characterized by excellent visibility and a direct grasping sensation. The backgrounds and complications of the patients were retrospectively investigated. Results: During this period, 954 patients (median age 4 months; range 1 day–73 years) underwent punch biopsy. Although there were no cases of severe complications (i.e., rectal perforation, infection or full-thickness biopsy), one (0.1%) of the 954 cases in the early period showed liver dysfunction and required transfusion due to bleeding. In addition, inappropriate specimens were obtained in 37 patients (3.9%). Conclusion: Punch biopsy including the “K-PUNCH” method is considered safe and feasible and is associated with a low rate of complications and inappropriate specimen harvesting among patients of all ages. Comorbidities, including the potential for hemorrhage, should always be considered.

UR - http://www.scopus.com/inward/record.url?scp=84994749755&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994749755&partnerID=8YFLogxK

U2 - 10.1007/s00383-016-4010-2

DO - 10.1007/s00383-016-4010-2

M3 - Article

C2 - 27832330

AN - SCOPUS:84994749755

VL - 33

SP - 173

EP - 179

JO - Pediatric Surgery International

JF - Pediatric Surgery International

SN - 0179-0358

IS - 2

ER -