The evolution of surgical treatment for gastrointestinal cancers

Yoshihiko Maehara, Yuji Soejima, Tomoharu Yoshizumi, Naoyuki Kawahara, Eiji Oki, Hiroshi Saeki, Tomohiko Akahoshi, Toru Ikegami, Yo ichi Yamashita, Tadashi Furuyama, Keishi Sugimachi, Noboru Harada, Tetsuzo Tagawa, Norifumi Harimoto, Shinji Itoh, Hideto Sonoda, Koji Ando, Yuichiro Nakashima, Yoshihiro Nagao, Nami YamashitaYuta Kasagi, Takafumi Yukaya, Takeshi Kurihara, Ryosuke Tsutsumi, Shinkichi Takamori, Shun Sasaki, Tetsuo Ikeda, Yoshikazu Yonemitsu, Takasuke Fukuhara, Hiroyuki Kitao, Makoto Iimori, Yuki Kataoka, Takeshi Wakasa, Masami Suzuki, Koji Teraishi, Yasuto Yoshida, Masaki Mori

Research output: Contribution to journalArticle

Abstract

Introduction: According to the latest Japanese nationwide estimates, over a million Japanese people are newly diagnosed with cancer each year. Since gastrointestinal cancers account for more than 40% of all cancer-related deaths, it is imperative to formulate effective strategies to control them. Materials and methods, and results: Basic drug discovery research Our research has revealed that the abnormal expression of regulators of chromosomal stability is a cause of cancers and identified an effective compound against cancers with chromosomal instability. We revealed the molecular mechanism of peritoneal dissemination of cancer cells via the CXCR4/CXCL12 axis to CAR-like cells and identified an MEK inhibitor effective against these tumors. Residual tumor cells after chemotherapy in colorectal cancer are LGR5-positive cancer stem cells and their ability to eliminate reactive oxygen species is elevated. The development of surgical procedures and devices In cases of gastric tube reconstruction for esophageal cancer, we determined the anastomotic line for evaluating the blood flow using ICG angiography and measuring the tissue O2 metabolism. We established a novel gastric reconstruction method (book-binding technique) for gastric cancer and a new rectal reconstruction method focusing on the intra-intestinal pressure resistance for rectal cancer. We established a novel tissue fusion method, which allows contact-free local heating and retains tissue viability with very little damage, and developed an understanding of the collagen-related processes that underpin laser-induced tissue fusion. Strategy to prevent carcinogenesis We succeeded in cleaving hepatitis B virus DNA integrated into the nucleus of hepatocytes using genome editing tools. The development of HCC from non-alcoholic steatohepatitis (NASH) may be prevented by metabolic surgery. Conclusion: We believe that these efforts will help to significantly improve the gastrointestinal cancer treatment and survival.

Original languageEnglish
Pages (from-to)1333-1349
Number of pages17
JournalInternational Journal of Clinical Oncology
Volume24
Issue number11
DOIs
Publication statusPublished - Nov 1 2019

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Gastrointestinal Neoplasms
Neoplasms
Chromosomal Instability
Stomach
Therapeutics
Tissue Survival
Bariatric Surgery
Neoplastic Stem Cells
Mitogen-Activated Protein Kinase Kinases
Residual Neoplasm
Fatty Liver
Drug Discovery
Esophageal Neoplasms
Rectal Neoplasms
Research
Hepatitis B virus
Heating
Stomach Neoplasms
Hepatocytes
Colorectal Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hematology
  • Oncology

Cite this

The evolution of surgical treatment for gastrointestinal cancers. / Maehara, Yoshihiko; Soejima, Yuji; Yoshizumi, Tomoharu; Kawahara, Naoyuki; Oki, Eiji; Saeki, Hiroshi; Akahoshi, Tomohiko; Ikegami, Toru; Yamashita, Yo ichi; Furuyama, Tadashi; Sugimachi, Keishi; Harada, Noboru; Tagawa, Tetsuzo; Harimoto, Norifumi; Itoh, Shinji; Sonoda, Hideto; Ando, Koji; Nakashima, Yuichiro; Nagao, Yoshihiro; Yamashita, Nami; Kasagi, Yuta; Yukaya, Takafumi; Kurihara, Takeshi; Tsutsumi, Ryosuke; Takamori, Shinkichi; Sasaki, Shun; Ikeda, Tetsuo; Yonemitsu, Yoshikazu; Fukuhara, Takasuke; Kitao, Hiroyuki; Iimori, Makoto; Kataoka, Yuki; Wakasa, Takeshi; Suzuki, Masami; Teraishi, Koji; Yoshida, Yasuto; Mori, Masaki.

In: International Journal of Clinical Oncology, Vol. 24, No. 11, 01.11.2019, p. 1333-1349.

Research output: Contribution to journalArticle

Maehara, Y, Soejima, Y, Yoshizumi, T, Kawahara, N, Oki, E, Saeki, H, Akahoshi, T, Ikegami, T, Yamashita, YI, Furuyama, T, Sugimachi, K, Harada, N, Tagawa, T, Harimoto, N, Itoh, S, Sonoda, H, Ando, K, Nakashima, Y, Nagao, Y, Yamashita, N, Kasagi, Y, Yukaya, T, Kurihara, T, Tsutsumi, R, Takamori, S, Sasaki, S, Ikeda, T, Yonemitsu, Y, Fukuhara, T, Kitao, H, Iimori, M, Kataoka, Y, Wakasa, T, Suzuki, M, Teraishi, K, Yoshida, Y & Mori, M 2019, 'The evolution of surgical treatment for gastrointestinal cancers', International Journal of Clinical Oncology, vol. 24, no. 11, pp. 1333-1349. https://doi.org/10.1007/s10147-019-01499-7
Maehara, Yoshihiko ; Soejima, Yuji ; Yoshizumi, Tomoharu ; Kawahara, Naoyuki ; Oki, Eiji ; Saeki, Hiroshi ; Akahoshi, Tomohiko ; Ikegami, Toru ; Yamashita, Yo ichi ; Furuyama, Tadashi ; Sugimachi, Keishi ; Harada, Noboru ; Tagawa, Tetsuzo ; Harimoto, Norifumi ; Itoh, Shinji ; Sonoda, Hideto ; Ando, Koji ; Nakashima, Yuichiro ; Nagao, Yoshihiro ; Yamashita, Nami ; Kasagi, Yuta ; Yukaya, Takafumi ; Kurihara, Takeshi ; Tsutsumi, Ryosuke ; Takamori, Shinkichi ; Sasaki, Shun ; Ikeda, Tetsuo ; Yonemitsu, Yoshikazu ; Fukuhara, Takasuke ; Kitao, Hiroyuki ; Iimori, Makoto ; Kataoka, Yuki ; Wakasa, Takeshi ; Suzuki, Masami ; Teraishi, Koji ; Yoshida, Yasuto ; Mori, Masaki. / The evolution of surgical treatment for gastrointestinal cancers. In: International Journal of Clinical Oncology. 2019 ; Vol. 24, No. 11. pp. 1333-1349.
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AU - Saeki, Hiroshi

AU - Akahoshi, Tomohiko

AU - Ikegami, Toru

AU - Yamashita, Yo ichi

AU - Furuyama, Tadashi

AU - Sugimachi, Keishi

AU - Harada, Noboru

AU - Tagawa, Tetsuzo

AU - Harimoto, Norifumi

AU - Itoh, Shinji

AU - Sonoda, Hideto

AU - Ando, Koji

AU - Nakashima, Yuichiro

AU - Nagao, Yoshihiro

AU - Yamashita, Nami

AU - Kasagi, Yuta

AU - Yukaya, Takafumi

AU - Kurihara, Takeshi

AU - Tsutsumi, Ryosuke

AU - Takamori, Shinkichi

AU - Sasaki, Shun

AU - Ikeda, Tetsuo

AU - Yonemitsu, Yoshikazu

AU - Fukuhara, Takasuke

AU - Kitao, Hiroyuki

AU - Iimori, Makoto

AU - Kataoka, Yuki

AU - Wakasa, Takeshi

AU - Suzuki, Masami

AU - Teraishi, Koji

AU - Yoshida, Yasuto

AU - Mori, Masaki

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