The expression of both peroxisome proliferator-activated receptor delta and cyclooxygenase-2 in tissues is associated with poor prognosis in colorectal cancer patients

Masahiro Yoshinaga, Kentaro Taki, Shinichi Somada, Yumiko Sakiyama, Norihiko Kubo, Toyoma Kaku, Satoru Tsuruta, Tetsuya Kusumoto, Hironori Sakai, Kazuhiko Nakamura, Ryoichi Takayanagi, Yoichi Muto

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Abstract

Background: The role of peroxisome proliferator-activated receptor delta (PPAR δ) in the development and progression of colorectal cancer (CRC) remains controversial. Aims: We investigated the impact of PPAR δ expression in tissues on liver metastasis of CRC. Methods: We analyzed samples of primary CRC and matched normal adjacent tissues from 52 patients for the expression of PPAR δ, cyclooxygenase (COX)-2, vascular endothelial growth factor (VEGF)-A, and CXC chemokine receptor 4 (CXCR4). Correlations of the molecules expressions with clinical characteristics and prognosis of patients were studied. Results: The number of patients positive for PPAR δ, COX-2, CXCR4, and VEGF-A was 25, 33, 18, and 19, respectively. Among the PPAR δ (+)/COX-2 (+), PPAR δ (-)/COX-2 (+), PPAR δ (+)/COX-2 (-), and PPAR δ (-)/COX-2 (-) patient groups, PPAR δ (+)/COX-2 (+) patients had the highest incidence of liver metastasis (p < 0.01). PPAR δ (+)/COX-2 (+) expression was a significant independent prognostic factor (HR = 7.108, 95% CI 1.231-41.029, p = 0.0283) by Cox proportional analysis. PPAR δ (+)/COX-2 (+) patients had the highest positivity for CXCR4 or VEGF-A in tissues (p < 0.01). Among the patients in the CXCR4 (+)/VEGF-A (+), CXCR4 (+)/VEGF-A (-), CXCR4 (-)/VEGF-A (+), and CXCR4 (-)/VEGF-A (-) groups, CXCR4 (+)/VEGF-A (+) patients had the highest incidence of liver metastasis (p < 0.01). Conclusions: The expression of both PPAR δ and COX-2 in tissues may lead to liver metastasis and consequent poor prognosis in CRC patients.

Original languageEnglish
Pages (from-to)1194-1200
Number of pages7
JournalDigestive Diseases and Sciences
Volume56
Issue number4
DOIs
Publication statusPublished - Apr 1 2011

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PPAR delta
Cyclooxygenase 2
CXCR4 Receptors
Colorectal Neoplasms
Vascular Endothelial Growth Factor A
Neoplasm Metastasis
Liver
Incidence

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

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The expression of both peroxisome proliferator-activated receptor delta and cyclooxygenase-2 in tissues is associated with poor prognosis in colorectal cancer patients. / Yoshinaga, Masahiro; Taki, Kentaro; Somada, Shinichi; Sakiyama, Yumiko; Kubo, Norihiko; Kaku, Toyoma; Tsuruta, Satoru; Kusumoto, Tetsuya; Sakai, Hironori; Nakamura, Kazuhiko; Takayanagi, Ryoichi; Muto, Yoichi.

In: Digestive Diseases and Sciences, Vol. 56, No. 4, 01.04.2011, p. 1194-1200.

Research output: Contribution to journalArticle

Yoshinaga, M, Taki, K, Somada, S, Sakiyama, Y, Kubo, N, Kaku, T, Tsuruta, S, Kusumoto, T, Sakai, H, Nakamura, K, Takayanagi, R & Muto, Y 2011, 'The expression of both peroxisome proliferator-activated receptor delta and cyclooxygenase-2 in tissues is associated with poor prognosis in colorectal cancer patients', Digestive Diseases and Sciences, vol. 56, no. 4, pp. 1194-1200. https://doi.org/10.1007/s10620-010-1389-9
Yoshinaga, Masahiro ; Taki, Kentaro ; Somada, Shinichi ; Sakiyama, Yumiko ; Kubo, Norihiko ; Kaku, Toyoma ; Tsuruta, Satoru ; Kusumoto, Tetsuya ; Sakai, Hironori ; Nakamura, Kazuhiko ; Takayanagi, Ryoichi ; Muto, Yoichi. / The expression of both peroxisome proliferator-activated receptor delta and cyclooxygenase-2 in tissues is associated with poor prognosis in colorectal cancer patients. In: Digestive Diseases and Sciences. 2011 ; Vol. 56, No. 4. pp. 1194-1200.
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title = "The expression of both peroxisome proliferator-activated receptor delta and cyclooxygenase-2 in tissues is associated with poor prognosis in colorectal cancer patients",
abstract = "Background: The role of peroxisome proliferator-activated receptor delta (PPAR δ) in the development and progression of colorectal cancer (CRC) remains controversial. Aims: We investigated the impact of PPAR δ expression in tissues on liver metastasis of CRC. Methods: We analyzed samples of primary CRC and matched normal adjacent tissues from 52 patients for the expression of PPAR δ, cyclooxygenase (COX)-2, vascular endothelial growth factor (VEGF)-A, and CXC chemokine receptor 4 (CXCR4). Correlations of the molecules expressions with clinical characteristics and prognosis of patients were studied. Results: The number of patients positive for PPAR δ, COX-2, CXCR4, and VEGF-A was 25, 33, 18, and 19, respectively. Among the PPAR δ (+)/COX-2 (+), PPAR δ (-)/COX-2 (+), PPAR δ (+)/COX-2 (-), and PPAR δ (-)/COX-2 (-) patient groups, PPAR δ (+)/COX-2 (+) patients had the highest incidence of liver metastasis (p < 0.01). PPAR δ (+)/COX-2 (+) expression was a significant independent prognostic factor (HR = 7.108, 95{\%} CI 1.231-41.029, p = 0.0283) by Cox proportional analysis. PPAR δ (+)/COX-2 (+) patients had the highest positivity for CXCR4 or VEGF-A in tissues (p < 0.01). Among the patients in the CXCR4 (+)/VEGF-A (+), CXCR4 (+)/VEGF-A (-), CXCR4 (-)/VEGF-A (+), and CXCR4 (-)/VEGF-A (-) groups, CXCR4 (+)/VEGF-A (+) patients had the highest incidence of liver metastasis (p < 0.01). Conclusions: The expression of both PPAR δ and COX-2 in tissues may lead to liver metastasis and consequent poor prognosis in CRC patients.",
author = "Masahiro Yoshinaga and Kentaro Taki and Shinichi Somada and Yumiko Sakiyama and Norihiko Kubo and Toyoma Kaku and Satoru Tsuruta and Tetsuya Kusumoto and Hironori Sakai and Kazuhiko Nakamura and Ryoichi Takayanagi and Yoichi Muto",
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T1 - The expression of both peroxisome proliferator-activated receptor delta and cyclooxygenase-2 in tissues is associated with poor prognosis in colorectal cancer patients

AU - Yoshinaga, Masahiro

AU - Taki, Kentaro

AU - Somada, Shinichi

AU - Sakiyama, Yumiko

AU - Kubo, Norihiko

AU - Kaku, Toyoma

AU - Tsuruta, Satoru

AU - Kusumoto, Tetsuya

AU - Sakai, Hironori

AU - Nakamura, Kazuhiko

AU - Takayanagi, Ryoichi

AU - Muto, Yoichi

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Background: The role of peroxisome proliferator-activated receptor delta (PPAR δ) in the development and progression of colorectal cancer (CRC) remains controversial. Aims: We investigated the impact of PPAR δ expression in tissues on liver metastasis of CRC. Methods: We analyzed samples of primary CRC and matched normal adjacent tissues from 52 patients for the expression of PPAR δ, cyclooxygenase (COX)-2, vascular endothelial growth factor (VEGF)-A, and CXC chemokine receptor 4 (CXCR4). Correlations of the molecules expressions with clinical characteristics and prognosis of patients were studied. Results: The number of patients positive for PPAR δ, COX-2, CXCR4, and VEGF-A was 25, 33, 18, and 19, respectively. Among the PPAR δ (+)/COX-2 (+), PPAR δ (-)/COX-2 (+), PPAR δ (+)/COX-2 (-), and PPAR δ (-)/COX-2 (-) patient groups, PPAR δ (+)/COX-2 (+) patients had the highest incidence of liver metastasis (p < 0.01). PPAR δ (+)/COX-2 (+) expression was a significant independent prognostic factor (HR = 7.108, 95% CI 1.231-41.029, p = 0.0283) by Cox proportional analysis. PPAR δ (+)/COX-2 (+) patients had the highest positivity for CXCR4 or VEGF-A in tissues (p < 0.01). Among the patients in the CXCR4 (+)/VEGF-A (+), CXCR4 (+)/VEGF-A (-), CXCR4 (-)/VEGF-A (+), and CXCR4 (-)/VEGF-A (-) groups, CXCR4 (+)/VEGF-A (+) patients had the highest incidence of liver metastasis (p < 0.01). Conclusions: The expression of both PPAR δ and COX-2 in tissues may lead to liver metastasis and consequent poor prognosis in CRC patients.

AB - Background: The role of peroxisome proliferator-activated receptor delta (PPAR δ) in the development and progression of colorectal cancer (CRC) remains controversial. Aims: We investigated the impact of PPAR δ expression in tissues on liver metastasis of CRC. Methods: We analyzed samples of primary CRC and matched normal adjacent tissues from 52 patients for the expression of PPAR δ, cyclooxygenase (COX)-2, vascular endothelial growth factor (VEGF)-A, and CXC chemokine receptor 4 (CXCR4). Correlations of the molecules expressions with clinical characteristics and prognosis of patients were studied. Results: The number of patients positive for PPAR δ, COX-2, CXCR4, and VEGF-A was 25, 33, 18, and 19, respectively. Among the PPAR δ (+)/COX-2 (+), PPAR δ (-)/COX-2 (+), PPAR δ (+)/COX-2 (-), and PPAR δ (-)/COX-2 (-) patient groups, PPAR δ (+)/COX-2 (+) patients had the highest incidence of liver metastasis (p < 0.01). PPAR δ (+)/COX-2 (+) expression was a significant independent prognostic factor (HR = 7.108, 95% CI 1.231-41.029, p = 0.0283) by Cox proportional analysis. PPAR δ (+)/COX-2 (+) patients had the highest positivity for CXCR4 or VEGF-A in tissues (p < 0.01). Among the patients in the CXCR4 (+)/VEGF-A (+), CXCR4 (+)/VEGF-A (-), CXCR4 (-)/VEGF-A (+), and CXCR4 (-)/VEGF-A (-) groups, CXCR4 (+)/VEGF-A (+) patients had the highest incidence of liver metastasis (p < 0.01). Conclusions: The expression of both PPAR δ and COX-2 in tissues may lead to liver metastasis and consequent poor prognosis in CRC patients.

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U2 - 10.1007/s10620-010-1389-9

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