The Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers

Yuta Kasagi, Eiji Oki, Kouji Andou, Shuhei Ito, Tomohiro Iguchi, Masahiko Sugiyama, Yuichiro Nakashima, Kippei Ohgaki, Hiroshi Saeki, Koshi Mimori, Yoshihiko Maehara

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Colon cancer-associated transcription 2 (CCAT2) was recently identified as a novel long noncoding RNA transcript encompassing the single-nucleotide polymorphism rs6983267. CCAT2 is overexpressed in colorectal cancer (CRC) where it promotes tumor growth, metastasis, and chromosomal instability, although the clinical relevance of this enhanced expression is unknown. In this retrospective study, CCAT2 expression was evaluated using real-time polymerase chain reaction in 149 CRC patients, and its associations with clinicopathological characteristics, outcome, rs6983267 genotypes, microsatellite status, DNA ploidy, and BubR1 expression were analyzed. CCAT2 expression in cancer tissue was significantly higher than in noncancer tissue (p < 0.001), particularly in cases of metastatic cancer (p < 0.001). However, relative CCAT2 expression levels and rs6983267 genotypes were not correlated with clinicopathological features or patient prognosis. CRC cases demonstrating high CCAT2 expression were all microsatellite stable (p < 0.005). Together, this indicates that CCAT2 expression was associated with microsatellite-stable CRC.

Original languageEnglish
Pages (from-to)48-54
Number of pages7
JournalOncology (Switzerland)
Volume92
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

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Long Noncoding RNA
Colonic Neoplasms
Single Nucleotide Polymorphism
Colorectal Neoplasms
Genotype
Microsatellite Repeats
Neoplasms
Chromosomal Instability
Ploidies
Real-Time Polymerase Chain Reaction
Retrospective Studies
Neoplasm Metastasis
DNA
Growth

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

The Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers. / Kasagi, Yuta; Oki, Eiji; Andou, Kouji; Ito, Shuhei; Iguchi, Tomohiro; Sugiyama, Masahiko; Nakashima, Yuichiro; Ohgaki, Kippei; Saeki, Hiroshi; Mimori, Koshi; Maehara, Yoshihiko.

In: Oncology (Switzerland), Vol. 92, No. 1, 01.01.2017, p. 48-54.

Research output: Contribution to journalArticle

Kasagi, Yuta ; Oki, Eiji ; Andou, Kouji ; Ito, Shuhei ; Iguchi, Tomohiro ; Sugiyama, Masahiko ; Nakashima, Yuichiro ; Ohgaki, Kippei ; Saeki, Hiroshi ; Mimori, Koshi ; Maehara, Yoshihiko. / The Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers. In: Oncology (Switzerland). 2017 ; Vol. 92, No. 1. pp. 48-54.
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