The Extracellular Matrix-Cell Interaction in ILD

Chandak Upagupta; Toyoshi Yanagihara; Martin Kolb

doi:10.1016/B978-0-08-102723-3.00021-4

The Extracellular Matrix-Cell Interaction in ILD

Chandak Upagupta, Toyoshi Yanagihara, Martin Kolb

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

Interstitial lung disease (ILD) is an umbrella term for a group of disorders characterized by lung inflammation and progressive fibrosis. The extracellular matrix (ECM) is a structural scaffold for cells, which provides mechanical stability and elastic recoil necessary for proper lung function. In fibrotic ILD, the ECM undergoes structural and biochemical changes, creating a pathological microenvironment for cells. Here we explore these changes, and how they interact with cells to facilitate progressive lung fibrosis in ILD.

Original language	English
Title of host publication	Encyclopedia of Respiratory Medicine, Second Edition
Publisher	Elsevier
Pages	126-134
Number of pages	9
Volume	3
ISBN (Electronic)	9780081027240
ISBN (Print)	9780081027233
DOIs	https://doi.org/10.1016/B978-0-08-102723-3.00021-4
Publication status	Published - Jan 1 2021
Externally published	Yes

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1016/B978-0-08-102723-3.00021-4

Cite this

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AB - Interstitial lung disease (ILD) is an umbrella term for a group of disorders characterized by lung inflammation and progressive fibrosis. The extracellular matrix (ECM) is a structural scaffold for cells, which provides mechanical stability and elastic recoil necessary for proper lung function. In fibrotic ILD, the ECM undergoes structural and biochemical changes, creating a pathological microenvironment for cells. Here we explore these changes, and how they interact with cells to facilitate progressive lung fibrosis in ILD.

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BT - Encyclopedia of Respiratory Medicine, Second Edition

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ER -

The Extracellular Matrix-Cell Interaction in ILD

Abstract

All Science Journal Classification (ASJC) codes

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