The Extracellular Matrix-Cell Interaction in ILD

Chandak Upagupta, Toyoshi Yanagihara, Martin Kolb

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


Interstitial lung disease (ILD) is an umbrella term for a group of disorders characterized by lung inflammation and progressive fibrosis. The extracellular matrix (ECM) is a structural scaffold for cells, which provides mechanical stability and elastic recoil necessary for proper lung function. In fibrotic ILD, the ECM undergoes structural and biochemical changes, creating a pathological microenvironment for cells. Here we explore these changes, and how they interact with cells to facilitate progressive lung fibrosis in ILD.

Original languageEnglish
Title of host publicationEncyclopedia of Respiratory Medicine, Second Edition
Number of pages9
ISBN (Electronic)9780081027240
ISBN (Print)9780081027233
Publication statusPublished - Jan 1 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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