The Fanconi anemia pathway: Insights from somatic cell genetics using DT40 cell line

Minoru Takata, Masamichi Ishiai, Hiroyuki Kitao

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

The Fanconi anemia (FA) pathway is a complex phosphorylation-ubiquitination network in the DNA damage signaling, which is still poorly understood. Defects in the "FA pathway" or in the related DNA repair proteins cause FA, a hereditary disorder that accompanies compromised DNA crosslink repair, poor hematopoetic stem cell survival, genomic instability, and cancer. For molecular dissection of the FA pathway, we have been using chicken B cell line DT40 as a model system. In this review, we will summarize our current understanding of the pathway, and discuss how studies using DT40 have contributed to this rapidly evolving field.

Original languageEnglish
Pages (from-to)92-102
Number of pages11
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume668
Issue number1-2
DOIs
Publication statusPublished - Jul 31 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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