Abstract
Background and Objective To examine the association between the features of metabolic syndrome (MetS) (obesity, hypertension, diabetes mellitus, and dyslipidemia) and the risk of biochemical recurrence (BCR) after radical prostatectomy in patients with prostate cancer. Methods This study included 283 Japanese patients with localized prostate cancer who were treated with radical prostatectomy between 2008 and 2012. Their oncological outcomes and the prognostic significance of several clinicopathological factors, as well as the features of MetS, were analyzed. Results Of 283 men who underwent radical prostatectomy, 49 (17.2%) subsequently developed BCR with a median postoperative follow-up of 14.8 months. Among the clinicopathological factors, prostate-specific antigen (PSA) level at diagnosis, pathological stage, pathological Gleason score, and lymph-node involvement were independent risk factors for BCR in multivariate analysis. In addition, the number of metabolic risk factors was also an independent risk factor for BCR. Conclusions The features of MetS were linked with poorer outcome after radical prostatectomy among Japanese men. Further investigations are needed to determine the effect of improving MetS on prostate cancer prognosis.
| Original language | English |
|---|---|
| Pages (from-to) | 476-481 |
| Number of pages | 6 |
| Journal | Journal of Surgical Oncology |
| Volume | 110 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jan 1 2014 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oncology
Cite this
The feature of metabolic syndrome is a risk factor for biochemical recurrence after radical prostatectomy. / shiota, masaki; Yokomizo, Akira; takeuchi, ario; Imada, Kenjiro; Kiyoshima, Keijiro; Inokuchi, Junichi; Tatsugami, Katsunori; Naito, Seiji.
In: Journal of Surgical Oncology, Vol. 110, No. 4, 01.01.2014, p. 476-481.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The feature of metabolic syndrome is a risk factor for biochemical recurrence after radical prostatectomy
AU - shiota, masaki
AU - Yokomizo, Akira
AU - takeuchi, ario
AU - Imada, Kenjiro
AU - Kiyoshima, Keijiro
AU - Inokuchi, Junichi
AU - Tatsugami, Katsunori
AU - Naito, Seiji
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Background and Objective To examine the association between the features of metabolic syndrome (MetS) (obesity, hypertension, diabetes mellitus, and dyslipidemia) and the risk of biochemical recurrence (BCR) after radical prostatectomy in patients with prostate cancer. Methods This study included 283 Japanese patients with localized prostate cancer who were treated with radical prostatectomy between 2008 and 2012. Their oncological outcomes and the prognostic significance of several clinicopathological factors, as well as the features of MetS, were analyzed. Results Of 283 men who underwent radical prostatectomy, 49 (17.2%) subsequently developed BCR with a median postoperative follow-up of 14.8 months. Among the clinicopathological factors, prostate-specific antigen (PSA) level at diagnosis, pathological stage, pathological Gleason score, and lymph-node involvement were independent risk factors for BCR in multivariate analysis. In addition, the number of metabolic risk factors was also an independent risk factor for BCR. Conclusions The features of MetS were linked with poorer outcome after radical prostatectomy among Japanese men. Further investigations are needed to determine the effect of improving MetS on prostate cancer prognosis.
AB - Background and Objective To examine the association between the features of metabolic syndrome (MetS) (obesity, hypertension, diabetes mellitus, and dyslipidemia) and the risk of biochemical recurrence (BCR) after radical prostatectomy in patients with prostate cancer. Methods This study included 283 Japanese patients with localized prostate cancer who were treated with radical prostatectomy between 2008 and 2012. Their oncological outcomes and the prognostic significance of several clinicopathological factors, as well as the features of MetS, were analyzed. Results Of 283 men who underwent radical prostatectomy, 49 (17.2%) subsequently developed BCR with a median postoperative follow-up of 14.8 months. Among the clinicopathological factors, prostate-specific antigen (PSA) level at diagnosis, pathological stage, pathological Gleason score, and lymph-node involvement were independent risk factors for BCR in multivariate analysis. In addition, the number of metabolic risk factors was also an independent risk factor for BCR. Conclusions The features of MetS were linked with poorer outcome after radical prostatectomy among Japanese men. Further investigations are needed to determine the effect of improving MetS on prostate cancer prognosis.
UR - http://www.scopus.com/inward/record.url?scp=84905726352&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905726352&partnerID=8YFLogxK
U2 - 10.1002/jso.23677
DO - 10.1002/jso.23677
M3 - Article
C2 - 24898352
AN - SCOPUS:84905726352
VL - 110
SP - 476
EP - 481
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 4
ER -